摘要
中药黄芪活性成分毛蕊异黄酮(CA),是从黄芪中提取出的功能性植物雌激素异黄酮,具有高效、毒副作用小、多靶点等特性,包含抗氧化、抗辐射、抗菌、保护心脑血管、增强免疫等多重药理作用。此外,多项研究还发现CA具有显著的抗肿瘤生物作用,有望成为治疗恶性肿瘤的潜在药物成分。研究表明,CA可通过多种作用机制发挥抗肿瘤作用,例如诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖及迁移及侵袭等,且CA在乳腺癌、结直肠癌、肺癌、宫颈癌、卵巢癌、鼻咽癌等多种常见恶性肿瘤中均有研究表明具有抗肿瘤功效,其抗肿瘤活性的作用机制主要体现于可通过调节B细胞淋巴瘤-2(Bcl-2)家族基因,微小RNA(miRNA),雌激素受体β(ERβ)触发肿瘤细胞凋亡;其抗增殖活性主要体现在对周期蛋白(Cyclin)家族,WD repeatcontaining protein 7(WDR7-7)蛋白,尤文肉瘤相关转录物1(EWSAT1)等的调节作用;通过阻断上皮间质转化(EMT)进程,血管内皮生长因子(VEGF),基质金属蛋白酶(MMP)抑制肿瘤细胞的转移和侵袭。此外,还可通过调节自噬标志物-1(Beclin-1)诱导肿瘤细胞自噬发挥抗肿瘤作用,且CA还可增强对化疗药物的敏感性以加强治疗效果。虽CA抗肿瘤研究基数较大,作用广泛,效果佳,但缺乏对CA抗肿瘤作用机制的系统性综述,为此,本研究基于CA抗肿瘤作用机制进行文献综述,以期为科研研究者和临床工作者提供借鉴及信息参考。
Calycosin(CA),a functional phytoestrogenic isoflavone extracted from Chinese herb Astragali Radix,is characterized by high efficiency,low toxicity,and multiple targets and has multiple pharmacological activities such as anti-oxidation,anti-radiation,anti-bacteria,cardio-cerebrovascular protection,and immunity enhancement.A number of studies have proved its significant anti-tumor effect,making it expected to become a potential component for the treatment of malignant tumors.Research shows that CA exerts the anti-tumor effect via multiple mechanisms like inducing tumor cell apoptosis and inhibiting tumor cell proliferation,migration,and invasion.It has been proved to be effective in suppressing breast cancer,colorectal cancer,lung cancer,cervical cancer,ovarian cancer,nasopharyngeal cancer,and other common malignant tumors.Its anti-tumor activity is mainly related to the regulation of B-cell lymphoma-2(Bcl-2)family genes,microRNA(miRNA),and estrogen receptorβ(ERβ)to trigger tumor cell apoptosis.Its antiproliferation activity is mainly reflected in the regulation of cyclin family,WD repeat-containing protein 7(WDR7-7),and Ewing sarcoma-associated transcript 1(EWSAT1).By blocking the epithelial mesenchymal transformation(EMT),vascular endothelial growth factor(VEGF),matrix metalloproteinases(MMPs),CA inhibits tumor cell metastasis and invasion.In addition,it inhibits tumors by regulating autophagy marker Beclin-1 induced tumor cell autophagy and increases the sensitivity to chemotherapy drugs,thus improving the treatment effect.Although there are many reports about the wide range of applications and good effects of CA in anti-tumor,the systematic review of its anti-tumor mechanism is still lacking.Therefore,this study reviewed the anti-tumor effects and mechanisms of CA,aiming to provide reference for researchers and clinical workers.
作者
王雪振
张小雨
牟悦
夏雷
张亚楠
WANG Xue-zhen;ZHANG Xiao-yu;MU Yue;XIA Lei;ZHANG Ya-nan(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第23期210-217,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81703839)。
