摘要
上皮间质转化(EMT)是在Twist,Snail及Zeb等家族转录因子作用下,上皮细胞失去极性,获得迁移间质特性的过程。EMT在肿瘤发生、发展和转移等多阶段发挥着重要作用。某些中药有效成分可通过多靶点激活转录因子以及相关信号通路来抑制EMT,但在溶解性、稳定性、组织特异性和安全性等方面存在不足,从而限制其药效发挥。纳米递送系统可以增强中药有效成分抑制EMT介导的肿瘤转移效果,降低药物毒副作用,提高其成药性。该文对调控EMT的中药有效成分纳米递送系统及其在抑制肿瘤转移方面的研究进展进行了综述,为相关药物的研发提供了参考依据。
The epithelial-to-mesenchymal transition(EMT),a process during which cells undergo transition from a polarized epithelial phenotype to a non-polarized mesenchymal phenotype, executed by transcription factors of Twist,Snail and Zeb families. EMT plays an important role in multiple stages of cancer progression such as initiation,tumor growth,and metastasis. Some active ingredients from Chinese materia medica can inhibit EMT by regulating transcription factors and signaling pathways by multiple targets. However,their therapeutic effect was hindered due to various limitation such as solubility,stability,tissue specificity and safety.Therefore,in order to improve the druggability of active ingredients from Chinese materia medica,enhance the therapeutic effect in inhibiting tumor metastasis mediated by EMT and reduce the toxic and side effects,a variety of nano-drug delivery systems have been developed in recent years. Here,we made a review about these drug delivery systems modulating EMT and their research progress in inhibiting tumor metastasis.
作者
闫飞
刘颖
冯年平
YAN Fei;LIU Ying;FENG Nian-ping(School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第4期235-241,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81773913)。
关键词
上皮间质转化
中药有效成分
纳米递送系统
肿瘤转移
侵袭
无机纳米载体
信号通路
epithelial-to-mesenchymal transition
active ingredients from Chinese materia medica
nano-drug delivery systems
tumor metastasis
invasion
inorganic nanocarriers
signaling pathways
