摘要
目的:研究九叶青花椒Zanthoxylum armatum var.novemfolius果皮二氯甲烷部位的化学成分。方法:采用正、反相硅胶柱色谱、Sephedex LH-20凝胶柱色谱、中压制备色谱和半制备HPLC等技术对九叶青花椒二氯甲烷部位提取物进行化学成分分离,通过^(1)H-NMR、^(13)C-NMR等波谱学方法对分离得到的化合物结构鉴定。结果:从九叶青花椒果皮的二氯甲烷部位分离并鉴定出14个化合物,分别为:β-谷甾醇(1)、芝麻素(2)、(1R,2R,5R,6S)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxy-phenyl)-3,7-dioxabicyclo[3.3.0]octane(3)、辛夷脂素(4)、tambulin(5)、xanthoxylol-3,3-dimethylallyl ether(6)、孕烯醇酮(7)、(+)-piperitol(8)、(+)-pluviatilol(9)、(+)-xanthoxyol(10)、洋李素(11)、羟基-α-山椒素(12)、羟基-β-山椒素(13)、芳樟醇(14)。结论:其中,化合物3、9、10为首次从该属植物中分离得到,化合物1~13为首次从该植物中分离得到。
Objective:To study the chemical constituents from the dichloromethane extraction of Zanthoxylum armatum var.novemfolius pericarps.Methods:The dichloromethane extract of Zanthoxylum armatum var.novemfolius pericarps was isolated by silica gel column chromatography,Sephadex LH-20,medium pressure preparative chromatography and semi-preparative HPLC.The structures were identified by spectroscopic methods,including^(1)H-NMR,^(13)C-NMR.Results:Fourteen compounds were isolated from the dichloromethane extraction of Zanthoxylum armatum var.novemfolius pericarps and identified asβ-sitosterol(1),(+)-sesamin(2),(1R,2R,5R,6S)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxy-phenyl)-3,7-dioxabicyclo[3.3.0]octane(3),(+)-fargesin(4),tambulin(5),xanthoxylol-3,3-dimethylallyl ether(6),pregnenolone(7),(+)-piperitol(8),(+)-pluviatilol(9),(+)-xanthoxyol(10),prudomestin(11),hydroxy-α-sanshool(12),hydroxy-β-sanshool(13),β-linalool(14),respectively.Conclusion:Among them,compounds 3,9 and 10 are isolated from Zanthoxylum genus for the first time,compounds 1 to 13 are isolated from Zanthoxylum armatum var.novemfolius for the first time.
作者
曾庆鸿
孙燕
孟凡成
曾维友
池浩
周於强
陈敏
ZENG Qing-hong;SUN Yan;MENG Fan-cheng;ZENG Wei-you;CHI Hao;ZHOU Yu-qiang;CHEN Min(College of Pharmacy,Southwest University,Chongqing 400715,China;Agricultural Technology Extension Center of Jiangjin District,Chongqing 402260,China)
出处
《中药材》
CAS
北大核心
2021年第6期1392-1396,共5页
Journal of Chinese Medicinal Materials
基金
国家现代农业产业园建设子课题(BA202000331)
关键词
九叶青花椒
化学成分
木脂素
酰胺
Zanthoxylum armatum var.novemfolius
Chemical constituents
Lignans
Acylamide
