摘要
目的探讨Toll样受体(TLR)7、TLR9及髓样分化因子88(MyD88)在白癜风患者皮损及健康对照皮肤的表达差异及其意义.方法2016年6月至2018年6月,收集广州市皮肤病防治所白癜风患者24例,男12例,女12例,年龄5~65(28.75±13.12)岁,病程14d至20年.用免疫组织化学方法分别检测24例白癜风患者皮损、20例健康对照皮肤中TLR7、TLR9及MyD88表达.结果白癜风患者皮损中TLR7、MyD88表达水平高于健康对照组,与健康对照组相比,差异有统计学意义(P<0.05).TLR9表达高于健康对照组,但与健康对照组比较差异无统计学意义(P>0.05).结论TLR7、TLR9及MyD88在白癜风患者皮损表达均上调,提示白癜风的发生可能与TLR7、TLR9异常表达有关.
Objective To explore the differential expression of Toll-like receptor 7/9 and mye-loid differentiation factor 88(MyD88)in skin lesions between patients with vitiligo and healthy indi-viduals as well as their clinical significance.Methods We collected vitiligo patients in the Guangzhou Institute of Dermatology and Venerology from June 2016 to June 2018.There were 24 vitiligo pa-tients,12 males and 12 females,aged 5 to 65(28.75±13.12)years,with medical history of 14 days to 20 years.The expression levels of TLR7/9 and MyD88 in skin lesions were determined from 24 pa-tients with vitiligo and 20 healthy controls by immunohistochemistry.Results The expression levels of TLR7 and MyD88 in skin lesions were significantly higher in patients with vitiligo than that in the controls,and the difference was statistically significant.The expression level of TLR9 in skin lesions was significantly higher in patients with vitiligo than that in the controls,while no significant differ-ence was observed between the two groups.Conclusions The expression level of TLR7 and TLR9 is elevated in skin lesions from patients with vitiligo.The abnormal expression level of TLR7 and TLR9 possibly participates in the pathogenesis of vitiligo。
作者
唐亚平
李振洁
张淑娟
李仰琪
刘玉梅
朱慧兰
Tang Yaping;Li Zhenjie;Zhang Shujuan;Li Yangqi;Liu Yumei;Zhu Huilan(Guangzhou Institute of Dermatology and Venerology,Guangzhou 510095,China)
出处
《中华医学美学美容杂志》
2020年第2期152-155,共4页
Chinese Journal of Medical Aesthetics and Cosmetology
基金
广东省医学科研基金项目(A2018288)。
