摘要
目的观察马首补白方联合复方甘草酸苷和他克莫司治疗稳定期白癜风的临床疗效以及对外周血肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)表达水平的影响。方法收集2020年9月-2021年12月中山大学附属第三医院皮肤科和南方医科大学皮肤病医院中西医结合皮肤科门诊收治的47例稳定期白癜风患者,将其随机分为常规治疗组(口服复方甘草酸苷片和外用他克莫司,n=26)和中药联合治疗组(口服马首补白方+复方甘草酸苷片和外用他克莫司,n=21),治疗3个月后评估临床疗效,并随机从2组治疗效果显效的患者中各自选取4例检测治疗前后TNF-α、IL-10水平变化。结果中药联合治疗组有效率66.67%(14/21),高于常规治疗组有效率50.00%(13/26),但差异无统计学意义(Z=0.979,P=0.322);常规治疗组和中药联合治疗组治疗后显效患者的外周血TNF-α水平较治疗前降低(t=3.127,P=0.052;t=3.051,P=0.055)、IL-10较治疗前升高(t=16.925,P<0.05;t=2.181,P=0.117);2组间治疗前后TNF-α、IL-10水平差异均无统计学意义(t=-0.446、1.012,-0.232、-0.793,P均>0.05)。中药联合治疗组有2例患者服药后出现恶心、腹胀不适,可自行缓解,其余患者随访过程中无诉头晕、头痛、胸闷等特殊不适,定期查血常规、肝肾功能指标无明显异常。结论马首补白方联合复方甘草酸苷口服和他克莫司外用治疗白癜风安全性较高,具有较好的临床疗效,治疗显效的患者外周血中TNF-α表达水平降低、IL-10升高。
Objective To observe the clinical efficacy of Ma Shou Bubai formula combined with compound glycyrrhizin and tacrolimus in the treatment of stable vitiligo and the effect of tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)expression levels in peripheral blood.Methods A total of 47 stable vitiligo patients admitted to the Department of Dermatology,the Third Affiliated Hospital of Sun Yat-sen University and Department of Integrative Chinese and Western Medicine,Dermatology Hospital of Southern Medical University From September 2020 to December 2021 were randomly divided into the conventional treatment group(take orally compound glycyrrhizin and topical tacrolimus,n=26)and the Traditional Chinese medicine combined treatment group(take orally Ma Shou Bubai formula combined with compound glycyrrhizin and topical tacrolimus,n=21).The clinical efficacy was evaluated after three months of the treatment,and the levels of TNF-αand IL-10 were detected in 4 patients severally from the two groups with remarkable therapeutic effect after the treatment.Results The effective rate was 66.67%(14/21)in the Traditional Chinese medicine combined treatment group and 50.00%(13/26)in the conventional treatment group,but there was no significant difference between the two groups(Z=0.979,P=0.322).The levels of TNF-αin the peripheral blood of the patients with remarkable therapeutic effect were decreased in conventional treatment group and Traditional Chinese medicine combined treatment group(t=3.127,P=0.052;t=3.051,P=0.055),while the levels of IL-10 were increased(t=16.925,P<0.05;t=2.181,P=0.117),and there was no statistical significance between the two groups before and after the treatment(t=-0.446,1.012;-0.232,-0.793;all P>0.05).In the Traditional Chinese medicine combined treatment group,2 patients had nausea and abdominal distension aftertaking the medicine,which could be relieved by themselves.The other patients had no special discomfort such as dizziness,headache and chest tightness during follow-up,and regular review of blood routine and liver and kidney function indexesshowed no obvious abnormalities.Conclusions Ma Shou Bubai formula combined with compound glycyrrhizin andtacrolimus in the treatment of vitiligo was relatively safe and had good clinical efficacy.The levels of TNF-αin peripheralblood of patients with remarkable therapeutic effect decreased while the levels of IL-10 increased.
作者
洪毅勇
罗光浦
谢和平
王天晶
黄影
朱琳
龚子鉴
HONG Yiyong;LUO Guangpu;XIE Heping;WANG Tianjing;HUANG Ying;ZHU Lin;GONG Zijian(Department of Dermatology,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510630,China;Department of Integrative Chinese and Western Medicine,Dermatology Hospital of Southern Medical University,Guangzhou,Guangdong 510030,China;Department of Traditional Chinese Medicine,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510630,China)
出处
《热带医学杂志》
CAS
2023年第12期1742-1745,共4页
Journal of Tropical Medicine
基金
广东省中医药局科研项目(20201060)
