摘要
目的:观察联合应用四妙丸水丸治疗急性痛风性关节炎的临床疗效。方法:选取2017年9月~2018年5月山东省潍坊市人民医院风湿免疫科收治的急性痛风性关节炎男性患者98例,按照随机数字表法分为观察组47例和对照组51例。对照组给予塞来昔布治疗,观察组采用塞来昔布联合四妙丸水丸治疗,两组均治疗14 d,随访3个月。观察两组患者局部关节症状、体征改善程度及时间,近期复发率,血尿酸、血沉等生化指标及药物不良反应发生情况。结果:本研究共完成93例,观察组脱落病例2例,对照组脱落病例3例,脱落患者皆为失访。治疗前,两组疼痛评分比较无显著性差异(P>0.05);治疗后,两组各时间点疼痛评分均较治疗前降低(P<0.05),观察组各时间点疼痛评分均低于对照组,但差异无统计学意义(P>0.05)。治疗前,两组血尿酸、血沉、白细胞计数等水平比较,差异无统计学意义(P>0.05);治疗14 d后,两组血尿酸、血沉、白细胞计数均较治疗前下降(P<0.05);观察组治疗后平均尿酸水平较对照组低,但差异无统计学意义(P>0.05),两组治疗后血沉、白细胞计数比较差异无统计学意义(P>0.05)。治疗期间,观察组不良反应发生率较对照组低,但差异无统计学意义(P>0.05)。随访3个月观察组复发率低于对照组(P<0.05)。结论:与单纯塞来昔布治疗相比,四妙丸联合塞来昔布治疗急性痛风性关节炎无明显增效作用及副反应,但可减少近期复发率。
Objective: To observe the clinical efficacy of Simiao pills combined with western medicine in the treatment of acute gouty arthritis. Methods: 98 Patients with acute gouty arthritis were randomly divided into two groups: 47 cases in the observation group were treated with Simiao pills and celecoxib, 51 cases in the control group were treated with celecoxib alone. All patients were treated for14 days, and followed up for 3 months.The local joint symptoms, signs of improvement and time;the recent recurrence rate, and uric acid,erythrocyte sedimentation rate, incidence of adverse effects were recorded. Results: A total of 93 cases were completed in this study. There were 2 cases of shedding in the observation group and 3 cases of shedding in the control group. All cases of shedding were due to loss of follow-up. Compared with before treatment, the joint pain score, UA and ESR were significantly lower after treatment(P<0.05). Before treatment, there was no significant difference in VAS scores between the two groups. After treatment, the VAS scores of the two groups were lower than those before treatment. The VAS scores of the observation group were lower than the control group at each time point, but the difference was not statistically significant. There was no significant difference between white blood cells and other biochemical indicators before and after treatment(P>0.05). There was no significant difference in VAS scores between the two groups(P>0.05).There was no significant difference between UA, ESR and WBC before and after treatment(P >0.05). The recurrence rate of the observation group was lower than that of the control group(P<0.05). Conclusion: Compared with celecoxib alone, Simiao pills combined with celecoxib has no obvious synergistic effect on acute gouty arthritis, but reducing recent recurrence is better.
作者
马菲菲
张萍
任通
王明超
李明
MA Fei-fei;ZHANG Ping;REN Tong;WANG Ming-chao;LI Ming(Weifang Medical University, Shandong,Weifang261042;Shandong Provincial Weifang City People's Hospital,Weifanng261000)
出处
《实用中西医结合临床》
2019年第9期1-2,145,共3页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
