摘要
目的探讨血清降钙素原(PCT)及其动态变化监测对于重症颅脑损伤患者开颅手术后早期诊断价值及预后预测价值.方法选取126例重症颅脑损伤并行开颅手术后患者,于不同时间点分别留取各个患者的血标本,并收集患者临床资料,根据有无感染分为感染组59例和未感染组67例.比较两组不同时间内体温峰值、白细胞计数、中性粒细胞百分数以及PCT等指标,分析PCT早期监测感染发生情况,并指导预后评估.结果感染组血清PCT水平每个时段均高于对照组,差异具有统计学意义(P<0.05);此外,5例重症感染患者中有2例死亡,且PCT水平持续增高,而3例存活患者PCT水平随着临床症状的改善呈下降趋势.血清PCT与重症颅脑损伤患者开颅术后院内感染呈正相关.结论血清PCT在感染早期即可出现异常改变,并可在一定程度上反映患者的病情危重程度,参与预后评估.
Objective To explore the clinical significance of dynamic determination of serum procalcitonin（PCT） levels in the judgment of nosocomial infection and prognosis in patients with traumatic brain injury.Method A total of 126 patients with traumatic brain injury after craniotomy were selected and divided into infection group and non-infection group.The temperature,serum white blood cell count（WBC）,neutrophil（N）and PCT were compared between infection group and non-infection group.The relation between dynamic serum PCT level change and prognosis was studied.Results The level of serum PCT in infection group was higher than that in non-infection group and there was significant difference（P〈0.05）.5 patients with severe infection,2patients were dead with the level of serum PCT sustained increase,while 3 survived patients with the level of serum PCT decrease.Conclusion The alteration of serum PCT level may be used as one of the effective predictors for the nosocomial infection in patients with traumatic brain injury.
作者
姜威
卞留贯
贺子建
Jiang Wei Bian Liuguan He Zijian(Affiliated Ruijin Hospital, School of Medicine Shanghai Jiaotong University, Shanghai 200025, China Central Hospital of Shanghai Minxing District ,Shanghai 201199, China)
出处
《北华大学学报（自然科学版）》
CAS
2017年第2期217-219,共3页
Journal of Beihua University（Natural Science）
关键词
降钙素原
重症颅脑损伤
术后感染
procaleitonin
traumatic brain injury
nosocomial infection
