摘要
目的探讨开颅手术后颅内感染的发病率、死亡率和病原菌谱,为制订预防颅内感染措施提供依据。方法采用荟萃分析方法,对开颅术后颅内感染进行流行病学调查。结果共有46篇论文进入荟萃分析,其中有34篇论文用于开颅术后颅内感染发病率的统计,共调查43766例,发生颅内感染1137例,发病率为2.60%;有23篇论文提供了开颅术后颅内感染死亡的数据,918例颅内感染病人中死亡193例,死亡率为21.02%;26篇论文统计显示,颅内感染细菌培养阳性率为55.41%,金黄色葡萄球菌、表皮葡萄球及其它凝固酶阴性葡萄球菌占40.18%,铜绿假单胞菌、大肠艾希菌、肺炎克雷伯菌占32.28%,真菌占7.13%。结论我国开颅术后颅内感染以G+球菌为主,亦有不少真菌感染病例,临床上应予以高度重视并及时治疗。
Objective To explore the morbidity, mortality and pathogen spectrum of intracranial infection after craniotomy in order to provide a basis for making the control measures for intracranial infection. Methods Some articles were selected from all the collected articles relevant to intracranial infection after the craniotomy from Chinese data bases, and analyzed by meta-analysis. Results Forty-six articles were selected for meta-analysis. The data relative to the morbidity analysis of intracranial infection were extracted from 32 articles. The intracranial infection occurred in 1 137 of 43 766 patients undergoing the craniotomy. The incidence of intracranial infection is 2.60%. The data relative to the mortality analysis were extracted from 23 articles. One hundred and ninetythree patients died in 918 patients with intracranial infection. The mortality is 21.02%. The positive rate of bacteria culture is 55.41%. The main pathogens included S.aureus, S.epiderrnidis, coagulase negative staphylococcus （which accounted for 40.18%）, P.aeruginosa, E. coil, K.pneumoniae （which accounted for 32.28%）, and fungus which were accounted for 7.13%. Conclusions In China staphylococcus is the main pathogen of intracranial infection after the craniotomy, but fungus infection also occurs in a few patient undergoing craniotmmy. The intracranial infection after the craniotomy should be paid great attention to and actively prevented and treated.
出处
《中国临床神经外科杂志》
2007年第3期149-151,共3页
Chinese Journal of Clinical Neurosurgery
关键词
开颅手术后
颅内感染
荟萃分析
Craniotomy
Intracranial infection
Meta-analysis
