摘要
目的:探讨抑郁症的自杀行为与睡眠脑电图的关系。 方法:对6例有自杀行为的抑郁症、12例无自杀行为的抑郁症、10例正常对照者检测睡眠脑电图。分析睡眠进程、睡眠结构和快波睡眠的情况。 结果:①自杀组的醒起时间[(13.3±6.4)min]比对照组的[(3.1±2.8)min]明显延长(t=4.45,P<0.05),而非自杀组与对照组则差异无显著意义(P>0.05)。②非自杀组慢波睡眠l相百分率[(16.5±8.6)％]比自杀组[(8.4±1.7)％]和对照组[(10.0±1.9)％]显著为高(t=2.25,2.33,P均<0.05),而自杀组与对照组差异无显著性意义(P>0.05)。 结论:①醒起时间延长是抑郁症易感自杀行为的生物学标记。②抑郁症常伴有慢波睡眠1相百分率增加,如果抑郁很重,而慢波睡眠1相百分率反而正常化,预示自杀危险性增加。
AIM: To explore the relation between suicidal behavior and sleep elec-troencephalographic(EEG) parameters in depressive patients. METHODS: It was estimated for sleep EEG in 6 depressive patients with suicidal behavior, 12 depressive patients without suicidal behavior and 10 normal controls. The states of sleeping processes, sleeping structure and fast wave sleep were observed.
RESULTS: (1) Time from awake to get up was significantly longer in the depressive patients with suicidal behavior(13. 3 ±6. 4) than the normal control subjects(3. 1 ± 2. 8) (t =4. 45, P < 0. 05), whereas it was not significantly different between depressive patients without suicidal behavior and the normal controls (P > 0. 05); (2) The percent of slow wave sleep 1 stage was significantly higher in depressive patients without suicidal behavior [(6. 5±8.6)% ]than the depressive patients with suicidal behavior [ (8. 4 ± 1.7)%] and the normal control subjects [(10.0 ±1.9)% ] (t=2.25, 2, 33, P < 0. 05), whereas there was no significant difference between the depressive patients with suicidal behavior and the normal control subjects( P > 0.05).
CONCLUSION: (1) Overtime from awake to get up is a biologic marker of susceptible suicidal behavior in depressive patients, (2) It was usually increased for slow wave sleep 1 stage percent in depressive patients. If depression is very severe, the slow wave sleep 1 stage percent will be normalized, whereas the latter could be used to predict suicide risk.
出处
《中国临床康复》
CSCD
2004年第9期1638-1639,共2页
Chinese Journal of Clinical Rehabilitation
基金
南京市跨世纪学科带头人后备人员专项基金(20028055)~~
