摘要
目的 探讨血管内皮生长因子 (VEGF)与基质金属蛋白酶 -9(MMP -9)在喉癌组织中的表达及其与肿瘤血管生成的关系。方法 采用免疫组织化学方法 ,检测 42例喉癌组织中VEGF与MMP -9表达及肿瘤微血管计数 (MVC)。结果 VEGF阳性表达者MVC值 (2 3 .82± 3 .71)显著大于阴性表达者 (19.5 3± 5 .43 ) ,MMP -9阳性表达者MVC值 (2 4.16± 4.0 6)亦显著大于阴性表达者 (2 0 .93± 4.3 2 ) ,VEGF、MMP -9表达与喉癌分化程度、临床分期无关。结论 VEGF与MMP
Objective To investigate the relationship of the expression of vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9) with angiogenesis in laryngeal carcinoma.Methods VEGF,MMP-9 and microvessel count(MVC) were detected by immunohistochemical method in 42 laryngeal carcinoma specimens.Results The mean MVC was signifecantly higher in tumors with positive VEGF or MMP-9 than in tumors with negative VEGF or MMP-9(23.82 ±3.71 vs.19.53±5.43 for VEGF and 24.16±4.06 vs.20.93±4.23 for MMP-9).The expression of VEGF and MMP-9 did not correlate with the differentiation and clinical staging of laryngeal carcinoma.Conclusion VEGF and MMP-9 may play an important role in the process of neovascularization in laryngeal carcinoma.
出处
《实用癌症杂志》
2003年第4期374-376,共3页
The Practical Journal of Cancer
关键词
喉癌
血管内皮生长因子
基质金属蛋白酶9
微血管密度
免疫组织化学
Laryngeal carcinoma
Vascular endothelial growth factor(VEGF)
Matrix metalloproteinase-9(MMP-9)
Microvessel count(MVC)
