摘要
目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片口服治疗。研究组在对照组治疗的基础上给予小青龙汤加减治疗。观察两组患者临床疗效、肺功能[用力肺活量(forced vital capacity,FVC)、最大呼气流速(peak expiratory flow,PEF)以及第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)]、气道高反应性、复发情况,并检测血清白细胞介素(interleukin,IL)-4、IL-5与外周血嗜酸性粒细胞(eosinophil,EOS)水平。结果:研究组有效率91.30%,对照组有效率为76.09%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后FVC、PEF、FEV1水平高于对照组,差异有统计学意义(P<0.05)。研究组治疗后最小诱发累积量、促使气道阻力增加至基础值的135%所需要的组胺累积剂量高于对照组,差异有统计学意义(P<0.05)。研究组治疗后血清IL-4、IL-5与外周血EOS低于对照组,差异有统计学意义(P<0.05)。研究组复发率为19.05%(8/42),对照组复发率为42.86%(15/35),研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论:小青龙汤加减治疗治疗小儿支原体肺炎,能改善患者肺功能,减轻患儿气道高反应性,调节血清IL-4、IL-5水平以及外周血EOS水平,降低复发率。
Objective:To observe the clinical efficacy of Modified Minor Green Dragon Decoction on mycoplasma pneumonia in children.Methods:A total of 92 patients with mycoplasma pneumonia were divided into the control group and the study group according to the random number table method,with 46 cases in each group.The control group was given conventional treatment,budesonide aerosol neb⁃ulization during pneumonia acute stage,and montelukast chewable tablets for oral administration during pneumonia symptoms remission stage.The study group was given Modified Minor Green Dragon Decoction based on the treatment of the control group.The clinical effi⁃cacy,pulmonary function[including forced vital capacity(FVC),peak expiratory flow(PEF)and forced expiratory volume in the first second(FEV1)],airway hyperresponsiveness,recurrence of the two groups were observed,and the levels of serum interleukin(IL)⁃4,IL⁃5 and peripheral blood eosinophil(EOS)were detected.Results:The effective rate of the study group was 91.30%,while that of the control group was 76.09%,the effective rate of the study group was higher than that of the control group,and the difference was statisti⁃cally significant(P<0.05).After treatment,the levels of FVC,PEF and FEV1 in the study group were higher than those in the control group,with a statistically significant difference(P<0.05);the minimum cumulative dose of histamine required to increase airway re⁃sistance to 135%of the basic value in the study group was higher than that in the control group,with a statistically significant difference(P<0.05);the levels of serum IL⁃4,IL⁃5 and peripheral blood EOS in the study group were lower than those in the control group,with statistically significant differences(P<0.05).The recurrence rate in the study group was 19.05%(8/42),which was lower than that in the control group 42.86%(15/35),with a statistically significant difference(P<0.05).Conclusion:Modified Minor Green Dragon Decoction for the treatment of mycoplasma pneumonia in children can improve pulmonary function,reduce airway hyperresponsiveness,regulate serum IL⁃4,IL⁃5 and peripheral blood EOS levels,and reduce the recurrence rate.
作者
刘孝忠
昌雪琼
于圆圆
宾博平
LIU Xiaozhong;CHANG Xueqiong;YU Yuanyuan;BIN Boping(Shanghai Punan Hospital of Pudong New Area,Renji Hospital Punan Branch Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China,200125;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning,Guangxi,China,530015)
出处
《河南中医》
2024年第5期659-663,共5页
Henan Traditional Chinese Medicine
基金
上海市浦东新区卫生系统学科带头人培养计划项目(PWRd2021-12)。
关键词
小儿支原体肺炎
小青龙汤
肺功能
气道高反应性
《伤寒论》
张仲景
mycoplasma pneumonia in children
Minor Green Dragon Decoction
pulmonary function
airway hyperresponsiveness
Trea⁃tise on Cold Damage Diseases
Zhang Zhongjing
