摘要
自身免疫性疾病(autoimmune disease, AID)发病机制复杂。近年来,越来越多的证据表明,感染在驱动具有潜在遗传背景的AID的发生和进展中起关键作用,这为临床重新审视AID的诱因及可能机制提供了更广阔和新颖的视角。本文通过总结病原微生物与自身免疫/AID相关性的最新研究进展,旨在从病原学角度探讨常见AID的病因和发病机制,以期通过整合现有证据,加深对AID发病机制的认识,为疾病预防和临床诊疗提供有价值的见解。
The pathogenesis of autoimmune diseases(AID)is a complex process.In recent years,an increasing number of evidence has shown that infection plays a key role in driving the occurrence and progression of AID,particularly in individuals with underlying genetic predisposition.This provides a new and broader perspective for clinical examination of the causes and potential mechanisms of AID.In this review,we aim to summarize the latest research progress on the relationship between pathogenic microorganisms and autoimmunity/AID,with the goal of exploring the etiology and pathogenesis of common AID from an etiological perspective.By integrating existing evidence,we hope to deepen the understanding of AID pathogenesis and provide valuable insights for disease prevention,clinical diagnosis and treatment.
作者
程琳琳
李詹
李永哲
CHENG Linlin;LI Zhan;LI Yongzhe(Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《协和医学杂志》
CSCD
2023年第5期925-931,共7页
Medical Journal of Peking Union Medical College Hospital
基金
国家重点研发计划(2018YFE0207300)
中央高水平医院临床科研专项(2022⁃PUMCH⁃B⁃124)
北京市自然科学基金(M23008,7234383)
中国博士后科学基金(2023T160060)。
