摘要
溃疡性结肠炎是临床上较为常见的消化道顽疾,难以治愈。中医药治疗此病具有独特的优势,取得了确切的临床治疗效果,但具体的作用机制尚不明确。随着生物信息学的迅速发展,网络药理学应用于探讨中医药治疗疾病的机制,能从对多系统阐述药理作用机制,与中医的整体观相契合。本文根据网络药理学的研究思路,总结中医传统经典方剂在治疗溃疡性结肠炎中的现状,以期为中药防治溃疡性结肠炎的现代化开发与应用提供新的思路,进一步阐述中医传统理论的科学内涵。
Ulcerative colitis(UC) is a common chronic disease in the digestive tract,which is difficult to cure.Traditional Chinese medicine(TCM) has unique advantages in the treatment of UC and has achieved definite clinical efficacy,but the specific mechanism is still unclear.With the rapid development of bioinformatics,network pharmacology is applied to explore the mechanism of TCM in the treatment of diseases.It can elaborate the pharmacological mechanism of TCM from multiple systems,which is consistent with the holistic view of TCM.According to the research ideas of network pharmacology,this paper summarized the current application of classic TCM prescriptions in the treatment of UC to provide new ideas for the modern development and application of TCM in the prevention and treatment of UC and further expound the scientific connotation of TCM theory.
作者
黄业保
肖倩
李红梅
刘春强
HUANG Yebao;XIAO Qian;LI Hongmei;LIU Chunqiang(Liuzhou People′s Hospital Affiliated to Guangxi Medical University,Liuzhou 545006,China)
出处
《世界中医药》
CAS
2023年第4期560-565,共6页
World Chinese Medicine
基金
国家自然科学基金项目(82060866)——基于肠道菌群-宿主共代谢探讨六磨汤治疗慢传输型便秘大鼠的作用机制研究
广西自然科学基金项目(2017GXNSFAA198119)——从慢传输型便秘大鼠肠道微生态改变探讨六磨汤的治疗机制
广西中医药适宜技术开发与推广项目(GZSY20-58)——壮医脐环穴针刺治疗腹泻型肠易激综合征临床研究
广西壮族自治区中医药管理局自筹项目(GZZC2020380)——滋水清肝饮加减对围绝经期慢性便秘及对患者雌激素的影响。
关键词
溃疡性结肠炎
中医药
经典方剂
网络药理学
活性成分
靶点
信号通路
作用机制
综述
Ulcerative colitis
Traditional Chinese medicine
Classic prescriptions
Network pharmacology
Active ingredient
Target
Signaling pathway
mechanism
Review
