摘要
中药是一个多成分、多作用靶点和多作用途径的复杂系统,中药及其复方治疗疾病遵循整体观思想。网络药理学是系统生物学的重要组成部分,其整体性、系统性和注重药物间相互作用的特点与中医药学的基本特点相吻合,是一门从系统层面揭示中药对机体调控网络作用的新兴学科,为研究传统中药与现代药理学之间的相互关系搭建了桥梁。综述网络药理学在中药领域中的应用现状和存在的问题,并阐述了网络药理学的研究思路、关键技术及应用方法与策略,以期为采用网络药理学揭示中医药现代科学内涵提供指引和参考。
Chinese materia medica(CMM) is a complex system with multiple components, multiple targets and multiple pathways.CMM and its compound prescription for the treatment of diseases follow the thought of holistic view. As an important part in systems biology, network pharmacology is a new subject to reveal the role of traditional Chinese medicine in regulating the organism network at the system level, its characteristics of integrality, systematicness and emphasis on drug interactions are consistent with the basic features of traditional Chinese medicine. It has built a bridge for the study of the relationship between traditional Chinese medicine and modern pharmacology. The paper summarizes the present application status and existing problem of network pharmacology in the field of traditional Chinese medicine, and systematically describes the research thinking, key technology and application method and strategy of network pharmacology. It is the purpose to provide the guidance and reference for the reveal of the modern scientific connotation of traditional Chinese medicine with the network pharmacology.
作者
解静
高杉
李琳
徐一兰
高树明
于春泉
XIE Jing;GAO Shan;LI Lin;XU Yi-lan;GAO Shu-ming;YU Chun-quan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第10期2257-2265,共9页
Chinese Traditional and Herbal Drugs
基金
国家重点基础研究发展计划("973"计划)项目(2014CB542902)
关键词
网络药理学
中药
新药研发
作用机制
应用策略
network pharmacology
Chinese materia medica
research and development of new drug
mechanism
application strategy
