摘要
目的:分析重组人干扰素α-2b凝胶联合乳酸菌阴道胶囊治疗子宫颈高危型人乳头瘤(HPV)病毒持续感染患者的效果。方法:将广东医科大学附属东莞第一医院2020年1月-2021年1月收治的91例子宫颈高危型HPV病毒持续感染患者作为研究对象,按照随机数字表法分为对照组(45例,给予重组人干扰素α-2b凝胶治疗)和观察组(46例,在对照组基础上给予乳酸菌阴道胶囊治疗),观察两组临床疗效、炎症因子水平、HPV转阴率及阴道微生态恢复情况。结果:治疗后,观察组总有效率为89.13%,高于对照组的66.67%(P<0.05);治疗后,观察组白细胞介素-8(IL-8)低于对照组,白细胞介素-12(IL-12)、干扰素-γ(INF-γ)高于对照组(P<0.05);观察组治疗1、3、6个月时的HPV转阴率分别为28.26%、58.70%、84.78%,均高于对照组的11.11%、24.44%、53.33%(P<0.05);治疗后,观察组pH值、Nugent评分均低于对照组(P<0.05)。结论:重组人干扰素α-2b凝胶联合乳酸菌阴道胶囊治疗子宫颈高危型HPV病毒持续感染患者可通过提高临床疗效,增加HPV转阴率,抑制炎症反应,从而有效改善阴道微生态。
Objective:To analyze the efficacy of Recombinant Human Interferonα-2b Gel combined with Lactic Acid Bacteria Vaginal Capsules in the treatment of cervical high-risk human papilloma virus(HPV)persistent infection.Method:A total of 91 patients with persistent cervical high-risk HPV virus infection treated in Dongguan First Hospital Affiliated to Guangdong Medical University from January 2020 to January 2021 were selected.They were divided into the control group(45 cases receiving Recombinant Human Interferonα-2b Gel)and the observation group(46 cases receiving Lactic Acid Bacteria Vaginal Capsules on the basis of the control group)according to the random number table.The clinical efficacy,levels of inflammatory factors,HPV negative conversion rate and vaginal microecological recovery of the two groups were observed.Result:After treatment,the total effective rate in the observation group was 89.13%,which was higher than 66.67%in the control group(P<0.05).After treatment,the level of interleukin-8(IL-8)in the observation group was lower than that in the control group,while the levels of interleukin-12(IL-12)and interferon-γ(INF-γ)in the observation group were higher than those in the control group(P<0.05).The negative conversion rates of HPV in the observation group after one,three and six months of treatment were 28.26%,58.70%and 84.78%respectively,which were higher than 11.11%,24.44%and 53.33%of those in the control group(P<0.05).After treatment,pH value and Nugent score in the observation group were lower than those in the control group(P<0.05).Conclusion:The Recombinant Human Interferonα-2b Gel combined with Lactic Acid Bacteria Vaginal Capsules can effectively improve the vaginal microecology by improving the clinical efficacy,increasing the negative conversion rate of HPV,and inhibiting inflammatory reaction in the treatment of patients with cervical high-risk HPV virus persistent infection.
作者
李娟
田甜
冯永波
LI Juan;TIAN Tian;FENG Yongbo(Dongguan First Hospital Affiliated to Guangdong Medical University,Dongguan 523710,China;不详)
出处
《中外医学研究》
2022年第11期60-63,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
重组人干扰素Α-2B凝胶
乳酸菌阴道胶囊
高危型人乳头瘤病毒
阴道微生态
Recombinant Human Interferonα-2b Gel
Lactic Acid Bacteria Vaginal Capsules
High-risk human papilloma virus
Vaginal microecology
