摘要
目的:探讨利培酮与舍曲林联合治疗对精神分裂症患者血清炎症因子水平及自我认知功能的影响。方法:回顾性分析2018年3月-2020年12月于湖北科技学院附属第二医院接受治疗的72例精神分裂症患者的临床资料,按照用药方案将患者分为对照组和研究组,每组36例。对照组单用利培酮治疗,研究组利培酮与舍曲林联合治疗。比较两组临床疗效、血清炎症因子水平[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-2(IL-2)]、简明精神状态量表(MMSE)及阳性与阴性症状量表(PANSS)评分。结果:研究组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组MMSE量表各维度评分比较,差异均无统计学意义(P>0.05);治疗后,两组MMSE量表各维度评分均高于治疗前,且研究组均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组TNF-α、IL-6、IL-2水平比较,差异均无统计学意义(P>0.05);治疗后,研究组TNF-α、IL-6及IL-2水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组阳性症状、阴性症状、一般精神病理症状及PANSS总分比较,差异均无统计学意义(P>0.05);治疗后,两组阳性症状、阴性症状、一般精神病理症状及PANSS总分均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05)。结论:对精神分裂症患者施以利培酮联合舍曲林治疗,可有效调节血清炎症因子水平,改善自我认知功能及精神功能症状,并可刺激疗效提升,值得应用。
Objective:To investigate the effect of Risperidone combined with Sertraline on serum inflammatory factors and selfcognitive function in patients with schizophrenia.Method:The clinical data of 72 patients with schizophrenia who received treatment in the Second Affiliated Hospital of Hubei University of Science and Technology from March 2018 to December 2020 were retrospectively analyzed,and the patients were divided into control group and study group according to medication regimen,with 36 patients in each group.The control group was treated with Risperidone alone,and the study group was treated with Risperidone combined with Sertraline.Clinical efficacy,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-2(IL-2)],minimental state examination(MMSE)and positive and negative symptom scale(PANSS)scores were compared between two groups.Result:The total effective rate in study group was higher than that in control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant difference in the all dimension scores of MMSE scale between two groups(P>0.05);after treatment,the all dimension scores of MMSE scale in both groups were higher than those before treatment,and that in the study group was higher than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of TNF-α,IL-6 and IL-2 between two groups(P>0.05);after treatment,the levels of TNF-α,IL-6 and IL-2 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in positive symptoms,negative symptoms,general psychopathological symptoms and total PANSS scores between two groups(P>0.05);after treatment,positive symptoms,negative symptoms,general psychopathological symptoms and total PANSS scores in both groups were lower than those before treatment,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Risperidone combined with Sertraline treatment for schizophrenia patients can effectively regulate the levels of serum inflammatory factors,improve self-cognitive function and mental function symptoms,and can stimulate the improvement of curative effect,which is worthy of application.
作者
程文涛
王小洁
CHENG Wentao;WANG Xiaojie(The Second Affiliated Hospital of Hubei University of Science and Technology,Xianning 437100,China;不详)
出处
《中外医学研究》
2022年第6期1-5,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
利培酮
舍曲林
精神分裂症
炎症因子
自我认知功能
Risperidone
Sertraline
Schizophrenic
Inflammatory factors
Self cognitive function
