摘要
目的总结骨质疏松性骨折中药熏洗处方用药规律,为中药熏洗治疗推广应用提供借鉴。方法抽取河南省骨科医院2018年骨质疏松性骨折住院患者电子病历信息,建立熏洗处方数据库,采用R软件分析处方药物的使用频次、性味归经及药物、证-药之间的关联规则。结果熏洗方常用中药有透骨草(80.04%)、伸筋草(80.04%)、花椒(78.56%)、川芎(73.25%)、川乌(73.25%);熏洗方以温性药为主,药物归经主要为肝、肾、脾三经;关联分析可知,“透骨草→伸筋草”“(透骨草,花椒)→伸筋草”为最常用配伍组合;“脾肾气虚证→淫羊藿”“肝肾阴虚证→牛膝”“气滞血瘀证→红花”等为证-药关联分析的代表性规则;基于兴趣度挖掘的配伍组合是“红花”与“海桐皮”。结论骨质疏松性骨折中药熏洗方治法为“祛风湿以通经络、活血以止痛、兼顾补肝肾”。透骨草、伸筋草、淫羊藿等为核心的“骨松”组方有舒筋活络、益肾壮骨之功;红花、海桐皮、苏木等为核心的“软伤”组方有活血化瘀、祛风除湿之效。
Objective To analyze the component law of Chinese medicine prescription in fuming-washing therapy for osteoporotic fractures,and to provide the reference for the prospective application of the fuming-washing therapy.Methods Chinese medicine recipes for fuming-washing therapy were recorded in a database by extracting the electronic medical information from Henan Orthopedic Hospital in 2018.The frequency,meridian entry,the correlation among herbs,and core combination of herbs were analyzed by using the association rules.Statistical analysis was conducted with a R 1.4.1106 software.Results Five herbs with high frequency were garden balsam stem(80.04%),limonium sinense(80.04%),Sichuan pepper(78.56%),Chuanxiong(73.25%),and Chuanwu(73.25%).Fuming-washing prescription was mainly consisted of drugs with warm character.The meridian entries were mainly consisted of the liver,kidney,and spleen.Correlation analysis demonstrated that garden balsam stem-limonium sinense combination and garden balsam stem or Sichuan pepper-limonium sinense combination were the most common herb pairs.The correlation coefficient between syndromes and herbs revealed that syndrome of qi deficiency of spleen and kidney-epimedium,syndrome of yin deficiency of liver and kidney-root of bidentate achyranthes,and syndrome of qi stagnation and blood stasis-saffron were the representative rules.Saffron-sea paulownia bark was the core combination by using the interest measure.Conclusion Eliminating rheumatism to clear the meridians,invigorating blood and removing blood stasis to relieve pain,and taking care of nourishing the liver and kidney are the major treatment method for osteoporotic fractures.The Gusong prescription is mainly composed of garden balsam stem,limonium sinense,and epimedium with the efficacy of relaxing muscles and collaterals,nourishing the kidney,and strengthening bones.The soft-trauma recipe is consisted of saffron,sea paulownia bark,and logwood with the the efficacy of promoting blood circulation,dispelling wind and dampness,and removing blood stasis.
作者
赵雪茹
马利
李淑琪
李慧
苏晓川
赵移畛
ZHAO Xueru;MA Li;LI Shuqi;LI Hui;SU Xiaochuan;ZHAO Yizhen(Hubei University of Chinese Medicine,Wuhan 430065;Luoyang Orthopedic-Traumatological Hospital,Zhengzhou 450000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2022年第1期84-88,共5页
Chinese Journal of Osteoporosis
基金
河南省中医药健康信息服务平台建设方案研究课题(TCM2019004)。
关键词
中医药
骨质疏松性骨折
中药熏洗
组方规律
关联规则
Chinese traditional medicine
osteoporotic fracture
herbal fumigation
composition principle of prescription
association rules
