摘要
目的:探讨小青龙汤加减在外寒内饮型慢性阻塞性肺疾病(COPD)急性期(外寒内饮型)治疗中的应用价值,观察其对气道重塑、炎性因子、肺功能的影响。方法:将2018年4月至2020年2月因COPD急性期于我院就诊且中医证型属于外寒内饮型的94例患者纳入研究,均用随机数字表法分组。对照组47例采用西医常规治疗,观察组47例则联合小青龙汤加减治疗,治疗2 w后比较疗效。结果:与治疗前比较,治疗后两组总症状积分明显降低,甲壳质酶蛋白40(YKL-40)、转化生长因子-β1(TGF-β1)、血清白介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)含量明显降低,1秒率/肺功能指标用力肺活量(FEV1/FVC)比值、FFV1明显升高(P<0.05)。治疗后与对照组比较,观察组血清YKL-40、TGF-β1、IL-6、MMP-9含量明显降低(P<0.05);FVC、FEV1/FVC明显升高,主要症状总积分(咳嗽、胸闷、喘息)及次要症状总积分(恶寒、肢体酸痛)明显降低(P<0.05);观察组总有效率95.74%(45/47),明显高于对照组的74.47%(35/47)(P<0.05)。结论:对于COPD急性期(外寒内饮型)患者而言联合小青龙汤加减可减轻患者的气道炎症反应,改善肺功能,预防气道重塑,提高临床疗效。
Objective:To explore the application value of modified Xiaoqinglong Decoction in the treatment of chronic obstructive pulmonary disease(COPD) in the acute phase [Waihanneiyin(外寒内饮) syndrome in TCM],and observe its effects on airway remodeling, inflammatory factors, and lung function. Methods:Ninety-four COPD patients in the acute phase with Waihanneiyin(外寒内饮) syndrome in TCM presenting themselves in the Haikou Hospital of Traditional Chinese Medicine from April 2018 to February 2020 were included in the study and divided into a control group(n=47, conventional western medicine) and an observation group(n=47, western medicine combined with modified Xiaoqinglong Decoction) according to a random number table. The treatment lasted two weeks. Results:Compared with the conditions before treatment, the two groups after treatment showed reduced total symptom scores, decreased levels of serum chitinase-like protein 40(YKL-40), transforming growth factor-β1(TGF-β1), serum interleukin-6(IL-6), and matrix metalloproteinase-9(MMP-9), and increased ratio of forced expiratory volume in one second(FEV1)/forced vital capacity(FVC) and FEV1(P<0.05). Compared with the control group after treatment, the observation group showed decreased content of YKL-40, TGF-β1, IL-6, and MMP-9(P<0.05), increased FVC and FEV1/FVC, reduced scores of main symptoms(cough, chest tightness, and wheezing) and minor symptoms(aversion to cold and soreness and pain of limbs). The total effective rate in the observation group was 95.74%(45/47), higher than 74.47%(35/47) in the control group(P<0.05). Conclusion:For COPD patients in the acute phase with Waihanneiyin(外寒内饮) syndrome in TCM,modified Xiaoqinglong Decoction combined with western medicine can relieve the airway inflammation in patients, improve lung function, and prevent airway remodeling to improve clinical efficacy.
作者
陈荣
李海静
李娥
范良
张璐璐
Chen Rong;Li Haijing;Li E;Fan Liang;Zhang Lulu(Haikou Hospital of Traditional Chinese Medicine,Haikou 570000;Hainan Third People’s Hospital,Sanya 572000)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2021年第4期184-188,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
海南省卫生计生行业科研项目(编号:15A200059)
海南省卫生计生行业科研项目(编号:18A200005)。
关键词
小青龙汤
COPD急性期
外寒内饮型
气道重塑
气道炎症
肺功能
Xiaoqinglong Decoction
COPD in the acute phase
Waihanneiyin(外寒内饮)syndrome
airway remodeling
airway inflammation
lung function
