摘要
目的了解慢阻肺(COPD)感染细菌的分布及其耐药性,给临床诊治提供参考。方法对COPD感染患者进行痰培养鉴定及药敏试验,同时对检出的大肠埃希菌和肺炎克雷伯菌进行超广谱内酰胺酶(ESBLS)确正试验测定、金黄色葡萄球菌进行耐甲氧西林测定、卡他莫拉茵进行β内酰胺酶测定。结果共分离出475株细菌,主要为铜绿假单胞菌106株,其次为嗜麦芽寡养单胞菌47株、白色念珠菌45株、卡他莫拉菌44株、不动杆菌42株、肺炎克雷伯菌36株、金黄色葡萄球菌30株。大肠埃希菌及肺炎克雷伯菌的产ESBLS株检出率达53．3%和58．3%,MRSA检出率达73．3%,卡他莫拉菌中产β内酰胺酶株占93．2%。结论COPD患者的感染病原主要为革兰阴性杆菌,另外卡他莫拉菌和白色念珠菌也不容勿视。所检出的菌株对大多数抗生素呈高度耐药。
Objective To survey the distribution and the resistance of the bacteria from chronic obstructive pulmonary disease （COPD） patients with respiratory infection. Methods Sputum from COPD patients were cultured and drug sensitivity tests were carried out. Meanwhile ESBLs was detected from E. coli and k. pneumoniae respectively by double paper validating methods. Methicillin - resistant test and β- lactamase test were done with Staphyloeoccus aureus and Moraxella catarrhalis respectively. Results Totally 475 strains were isolated. The most common pathogen was Pseudomonas aeruginosa （106 strains）, followed by Strenotrophomonas maltophilia （47 strains）, Candida albicans （45 strains）, Moraxella catarrhalis （44 strains）, Acirwtobacter spp . （42 strains）, KlebsieUa pneumoniae （36 strains）, Staphylococeus aureus （30 strains）. The constituent ratios of E . coil and K. pneumoniae which could produce ESBLS, were 53.8% and 58.3% respectively. The rate of MRSA was 73.3% and the rate of Moraxella catarrhalis producing β- lactamase was 93.2%. Cobb.his｜on The pathogen of the COPD patients with respiratory in- fection was mostly gram - negative bacteria, but attention be also paid to MoraxeUa catarrhalis and Candida albicans. All the strains isolated from the COPD patients with respiratory infection are highly resistant to most antibiotics.
出处
《中国热带医学》
CAS
2007年第1期98-99,共2页
China Tropical Medicine
