摘要
白细胞介素-33(interleukin-33,IL-33)是IL-1家族的一位新成员,其不仅可以在细胞核内作为核因子发挥作用,也可以被损伤或坏死的细胞释放到细胞外作为细胞因子发挥作用。被释放的IL-33通过由特异性受体肿瘤发生抑制子2(suppression of tumorigenicity 2,ST2)及IL-1受体辅助蛋白(interleukin 1 receptor auxiliary protein,IL-1RAcP)组成的异构体激活下游的NF-κB和MAPKs信号通路,进一步激活多种免疫反应。IL-33在多种肿瘤(如肺癌、乳腺癌、结直肠癌等)中异常表达,参与肿瘤的发生、发展和转移,甚至在同一类肿瘤中同时发挥促肿瘤和抗肿瘤的双重作用。
Interleukin-33(IL-33)is a new member of the IL-1 cytokine family which plays roles in the nucleus as a nuclear factor and is released by damaged or necrotic cells to act as a cytokine.It can be released via damaged or necrotic cells and functions as a cytokine.The released IL-33 activates the downstream NF-κB and MAPKs signaling pathways through the isomers of the specific receptor ST2 and the interleukin-1 receptor accessory protein(IL-1RAcP),resulting in danger signals and the activated multiple immune responses.IL-33 is abnormally expressed in various tumors and involves in tumorigenesis,development,and metastasis.Moreover,IL-33 can play both pro-tumor and anti-tumor roles in the same type of tumor.
作者
刘茜茜
陆地
胡嘉华
梁俊朝
陈火英
LIU Qianqian;LU Di;HU Jiahua;LIANG Junchao;CHEN Huoying(Lingui College of Clinical Medicine,Guilin Medical University,Guilin Guangxi 541100;Department of Traditional Chinese Medical Orthopedics,Eighth People’s Hospital of Foshan,Foshan Guangdong 528200,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2021年第2期169-175,共7页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81860474)
广西自然科学基金(2018GXNSFBA281036)
广西高校中青年教师基础能力提升项目(2018KY0411)。
