摘要
目的:检测环状RNA has-circ-0037251在胶质瘤中的表达,探讨has-circ-0037251对脑胶质瘤患者的预后影响和临床价值。方法:回顾性分析56例脑胶质瘤患者的临床资料,采用荧光定量PCR技术(qRT-PCR)测定has-circ-0037251的表达,并分析其与胶质瘤患者临床病理特征的关系。应用Kaplan-Meier曲线评估生存率,采用单因素、多因素Cox回归法分析影响患者生存期的相关因素。结果:has-circ-0037251在胶质瘤组织中的表达相比正常脑组织显著增高,其表达水平与WHO分级和KPS评分有关系(均P<0.05),而与年龄、性别、肿瘤大小等无关(均P>0.05)。has-circ-0037251高表达组生存时间更短,高WHO分级、KPS评分<80、has-circ-0037251的高表达是影响患者预后的独立危险因素。结论:has-circ-0037251在胶质瘤患者中高表达,且为患者预后的独立危险因素,可作为胶质瘤患者预后的预测因子及潜在的研究和治疗靶点。
Objective:To detect the expression of cyclic RNA has-circ-0037251 in gliomas,and to explore the prognostic value of has-circ-0037251 in patients with gliomas.Methods:The clinical data of 56 patients with gliomas were retrospectively analyzed.The expression of has-circ-0037251 was detected by qRT-PCR,and its relationship with clinicopathological characteristics of glioma patients was analyzed.Kaplan-Meier curve was used to evaluate the survival rate,and univariate and multivariate Cox regression method was used to analyze the related factors affecting the survival time.Results:The expression of has-circ-0037251 in glioma tissues was significantly higher than that in normal brain tissues.The expression level of has-circ-0037251 was correlated with WHO classification and KPS score(all P<0.05),but not with age,gender and tumor size(all P>0.05).The survival time of patients with high expression of has-circ-0037251 was shorter.High WHO grade,KPS score<80 and high expression of has-circ-0037251 were independent risk factors for prognosis.Conclusion:Has-circ-0037251 is highly expressed in glioma patients and is an independent risk factor for prognosis.It can be used as a prognostic predictor and potential research and therapeutic target for glioma patients.
作者
徐泽彪
胡珍渊
方永军
王首杰
XU Zebiao;HU Zhenyuan;FANG Yongjun;WANG Shoujie(Department of Neurosurgery,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《陕西医学杂志》
CAS
2021年第2期229-232,共4页
Shaanxi Medical Journal
基金
国家自然科学基金青年科学基金资助项目(81901188)
陕西省中西医结合临床协作创新项目(2020-ZXY-007)。
