摘要
目的:探讨扣针蛋白5(Fibulin-5)、内皮细胞特异性分子-1(endothelial cell specific molecule-1,ESM-1)在心肌梗死患者中的动态变化及其临床意义。方法:选择2017-01-01~2018-12-01我院收治的120例心肌梗死患者为研究对象。检测患者入院时及治疗1 d、4 d、7 d、14 d后的Fibulin-5、ESM-1水平,分析心肌梗死主要不良心脏事件(major adverse cardiac events,MACE)发生的相关危险因素。结果:与入院时相比,心肌梗死患者治疗1 d后Fibulin-5、ESM-1水平均升高;而治疗4 d、7 d、14 d后逐渐下降,差异均有统计学意义(P<0.05或P<0.01)。单因素分析显示,年龄及Fibulin-5、ESM-1水平是发生心肌梗死MACE的主要影响因素。多因素Logistic回归分析表明,Fibulin-5、ESM-1水平是发生心肌梗死MACE的相关危险因素。结论:心肌梗死患者Fibulin-5、ESM-1水平与心肌梗死MACE的发生密切相关,两者在治疗1 d后达到高峰,随着治疗时间的延长水平均下降。
Objective:To explore the dynamic changes and clinical significance of Fibulin-5 and endothelial cell specific molecule-1(ESM-1)in patients with myocardial infarction.Methods:A total of 120 patients with myocardial infarction in our hospital from January 2017 to December 2018 were selected.Fibulin-5 and ESM-1 levels on admission and treatment of 1 d,4 d,7 d and 14 d were measured.The risk factors of major adverse cardiac events(MACE)in myocardial infarction were analyzed.Results:Compared with admission,the levels of Fibulin-5 and ESM-1 in patients with myocardial infarction after treatment of 1 day were increased,however,after treatment of 4 d,7 d and 14 d,it gradually decreased,and the difference was statistically significant(P<0.05 or P<0.01).Univariate analysis showed that age,Fibulin-5 level and ESM-1 level were the main influencing factors of myocardial infarction MACE.Multivariate Logistic regression analysis showed that Fibulin-5 level and ESM-1 level were risk factors of myocardial infarction MACE.Conclusion:Fibulin-5 and ESM-1 are closely related to the occurrence of myocardial infarction MACE,which reached a peak in serum of patients with myocardial infarction after treatment 1 d,and the level are decreased with the extension of treatment time.
作者
余金彪
韩升波
郭亚
YU Jinbiao;HAN Shengbo;GUO Ya.(Department of Clinical Laboratory,Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou 450007,China)
出处
《西北国防医学杂志》
CAS
2020年第12期741-744,共4页
Medical Journal of National Defending Forces in Northwest China
基金
河南省中医药科学研究专项课题(2010ZY3017)。
