摘要
目的:探讨高血压患者血清内皮细胞特异性分子-1(Endothelial cell-specific molecule-1,ESM-1)表达水平及其临床意义。方法:入选高血压患者130例,其中原发性单纯初诊未治疗高血压患者50例,高血压合并急性心肌梗死患者80例,同时纳入健康成年对照组60例,比较高血压组及高血压亚组与对照组、ESM-1表达水平差异,并进行相关性分析。结果:高血压组及高血压亚组ESM-1水平均明显高于对照组(P<0.05),高血压合并急性心肌梗死患者ESM-1水平明显高于单纯初诊高血压患者(P<0.05)。相关性分析表明,ESM-1水平与年龄、体重指数、肌酐、TC、TG、HDL-C、LDL-C、hs-CRP均无明显相关性(P均>0.05)。结论:ESM-1可能是高血压患者新型内皮功能紊乱生物标记物,可能与高血压患者未来发生心血管事件相关。
l： Objective： To investigate the expression of serum endothelial cell-specific molecule-1 level in patients with hypertension and its clinical significance. Methods： 130 patients with hypertension and 60 healthy individuals as a control group were included in the study,the hypertension patients conclude 50 primary newly diagnosed and untreated hypertensions and 80 hypertensions with acute myocardial infarction. Compared endothelial cell-specific molecule-1（ESM-1） levels between different groups and analysis of the correlationction between ESM-1 and other baseline characteristics. Results： There was a significant difference in serum ESM-1 levels between hypertension group and control group.The serum ESM-1 levels in subgroup of hypertension were also significantly different（all P〈0. 05）. Correlation analysis showed that,There was no significant correlation between serum ESM-1 level and age、body mass index、creatinine、TC、TG、HDL-C、LDL-C、hs-CRP（all P〈0. 05）. Conclusion： ESM-1 may be a novel biomarker of endothelial dysfunction in patients with hypertension and associate with future cardiovascular events.
作者
邱崇荣
付幼林
袁文金
陈丰
杨忠明
罗骏
QIU Chong-rong;FU You-lin;YUAN Wen-jing;CHENfen;YANG Zhong-ming;LUO Jun(Department of Cardiology,Ganzhou People＇s Hospital,Ganzhou,Jiangxi 34100)
出处
《赣南医学院学报》
2018年第5期456-459,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
江西省卫生计生委科技计划项目(项目编号:20184067)
赣州市指导性科技计划项目(GZ2016ZSF158)
关键词
高血压
内皮功能紊乱
内皮细胞特异性分子-1
心血管事件
hypertension
endothelial dysfunction
endothelial cell-specific molecule-1
cardiovascular events
