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冠心病患者血清内皮细胞特异性分子-1表达水平及其相关性 被引量:12

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摘要 目的探讨冠心病患者血清内皮细胞特异性分子(ESM)-1表达水平并分析其相关性。方法 300例行冠状动脉造影检查患者按造影结果分为冠心病组(230例)和对照组(非冠心病组,70例),所有入组患者检测血清ESM-1、超敏C反应蛋白(hs-CRP),计算中性粒细胞淋巴细胞比值(NLR)。比较两组血清ESM-1表达水平,并对冠心病组ESM-1进行相关性分析。结果与对照组比较,冠心病组ESM-1水平较高[(1.15±0.33)ng/ml vs(1.04±0.03)ng/ml,P<0.05]、hs-CRP水平较高[14.30(5.88,31.35)mg/L vs 6.28(0.85,17.60)mg/L,P<0.05]、NLR水平较高[6.48(3.88,11.04)vs 3.75(1.89,6.23),P<0.05]。冠心病患者ESM-1与hs-CRP及NLR呈正相关(r分别为0.128及0.139,P均<0.05)。结论 ESM-1可能是冠心病患者内皮功能紊乱生物标记物,可能与炎症介质共同参与冠心病发病过程。
作者 邱崇荣 罗骏
出处 《中国老年学杂志》 CAS 北大核心 2018年第14期3360-3363,共4页 Chinese Journal of Gerontology
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