摘要
小鼠移植性肺癌转移模型是进行肺癌研究的重要工具,对阐释肺癌的转移机制以及肺癌相关药物的研发都具有重要意义。本文综合考虑肺癌转移易发生的部位及肿瘤的种属差异,对该模型进行进一步分类,同时详细地论述了每种类型的建模方法、评价指标,为肺癌相关研究提供模型参考。
The metastatic model of transplanted lung cancer in mouse is an important tool in lung cancer research,and has great significance in interpreting the metastasis mechanism of lung cancer and in studying drugs related to lung cancer. In this paper, the frequent sites of lung cancer metastasis and the species differences of tumors were comprehensively considered,and this model was further classified,while the modeling method and evaluation index of each type were expounded in detail to provide model references for lung cancer-related research.
作者
张娜
田燕歌
刘学芳
王琦
ZHANG Na;TIAN Yange;LIU Xuefang;WANG Qi(College of Basic Medicine,Henan University of Chinese Medicine,Zhengzhou 450046;China.2.Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2020年第4期557-562,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
河南省重点研发与推广专项(192102310427)
河南省高等学校重点科研项目(20A360007)。
关键词
小鼠
肺癌
移植
转移模型
mouse
lung cancer
transplant
metastatic model
