摘要
目的:探讨miR-181b在冠心病慢性心力衰竭患者血清中的表达及其临床意义。方法:选取2017年3月到2018年10月期间在我院接受治疗的冠心病慢性心力衰竭患者103例作为心衰组,另选取同期在我院收治的单纯冠心病患者60例作为冠心病组,另选取同期在我院体检的健康志愿者60例作为对照组。比较三组研究对象的血清miR-181b、炎症因子、心功能指标。另根据美国纽约心脏病协会(NYHA)分级标准将103例冠心病慢性心力衰竭患者分为I-II级组(38例)、III级组(32例)、IV级组(33例)。比较不同心功能分级的冠心病慢性心力衰竭患者的血清miR-181b、炎症因子、心功能指标。分析冠心病慢性心力衰竭患者的血清miR-181b与炎症因子、心功能指标的相关性。结果:心衰组的肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、左室舒张末期内径(LVEDD)均高于冠心病组和对照组,miR-181b、左室射血分数(LVEF)低于冠心病组和对照组(P<0.05)。冠心病组的血清TNF-α、hs-CRP、IL-6、LVEDD均高于对照组,miR-181b、LVEF低于对照组(P<0.05),IV级组的血清TNF-α、hs-CRP、IL-6、LVEDD均高于III级组和I-II级组,miR-181b、LVEF低于III级组和I-II级组(P<0.05),III级组的血清TNF-α、hs-CRP、IL-6、LVEDD均高于I-II级组,miR-181b、LVEF低于I-II级组(P<0.05),Pearson分析结果显示,冠心病慢性心力衰竭患者血清miR-181b与TNF-α、hs-CRP、IL-6呈负相关,与LVEF呈正相关(P<0.05),与LVEDD无明显的相关性(P>0.05)。结论:miR-181b在冠心病慢性心力衰竭患者血清中呈异常低表达,且表达水平与炎症反应程度和LVEF存在一定相关性。
Objective:To investigate the expression and clinical significance of miR-181b in serum of patients with chronic heart failure due to coronary heart disease.Methods:A total of 103 patients with chronic heart failure due to coronary heart disease who were treated in our hospital from March 2017 to October 2018 were enrolled as the heart failure group.60 patients with coronary heart disease admitted to our hospital in the same period were selected as the coronary heart disease group.Another 60 healthy volunteers who were examined in our hospital during the same period were selected as the control group.Serum miR-181b,inflammatory factors and cardiac function were compared between the three groups.According to the New York Heart Association(NYHA)grading standard,103 patients with chronic heart failure of coronary heart disease were divided into group I-II(38 cases),group III(32 cases)and group IV(33 cases).Serum miR-181b,inflammatory factors and cardiac function were compared in patients with chronic heart failure due to coronary heart disease with different cardiac function grades.The correlation between serum miR-181b and inflammatory factors and cardiac function in patients with chronic heart failure due to coronary heart disease were analyzed.Results:The tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)and left ventricular end diastolic diameter(LVEDD)in the heart failure group were higher than those in the coronary heart disease group and control group,miR-181b and left ventricular ejection fraction(LVEF)were lower than those in the coronary heart disease group and the control group(P<0.05).The levels of serum TNF-α,hs-CRP,IL-6 and LVEDD were higher in the coronary heart disease group were higher than those in the control group,miR-181b and LVEF were lower than those in the control group(P<0.05).The levels of serum TNF-α,hs-CRP,IL-6 and LVEDD in group IV were higher than those in group III and I-II,miR-181b and LVEF were lower than those in group III and group I-II(P<0.05).The levels of serum TNF-α,hs-CRP,IL-6 and LVEDD in group III were higher than those in group I-II,and miR-181b and LVEF were lower than those in group I-II(P<0.05).Pearson analysis showed that serum miR-181b was negatively correlated with TNF-α,hs-CRP,IL-6,and positively correlated with LVEF in patients with chronic heart failure due to coronary heart disease(P<0.05),and had no significant correlation with LVEDD(P>0.05).Conclusion:miR-181b is abnormally low expressed in the serum of patients with chronic heart failure due to coronary heart disease,and the expression level is related to the degree of inflammatory reaction and LVEF.
作者
宫柏琪
张琳
王娜
李强
贺延
GONG Bai-qi;ZHANG Lin;WANG Na;LI Qiang;HE Yan(Department of Cardiovascular Medicine,Beijing Armed Police Corps Hospital,Beijing,100027,China)
出处
《现代生物医学进展》
CAS
2020年第11期2110-2113,2041,共5页
Progress in Modern Biomedicine
基金
北京市自然科学基金项目(7172351)。
关键词
慢性心力衰竭
冠心病
miR-181b
炎症因子
心功能
Chronic heart failure
Coronary heart disease
miR-181b
Inflammatory factors
Cardiac function
