摘要
目的探讨研究呼出气一氧化氮(FeNO)检测在毛细支气管炎患儿中的临床应用价值。方法选取2018年8月~2019年4月在惠州市第二妇幼保健院儿科病房住院的100例毛细支气管炎患儿作为研究对象,再选取相同年龄段相同时期进行检查非呼吸道疾病健康的儿童50例及无喘息支气管肺炎患儿50例。将100例毛细支气管炎患儿进行常规治疗,并在治疗初期及治疗后3个月与非呼吸道疾病健康的儿童及无喘息支气管肺炎患儿进行检测FeNO的水平比较,在8个月内对毛细支气管炎患儿进行哮喘复发情况的随访。结果毛细支气管炎组、无喘息支气管肺炎组患者FeNO水平比非呼吸道疾病健康组50例幼儿的FeNO水平低;毛细支气管炎组100例毛细支气管炎患儿在3个月后FeNO水平相比与初期检测FeNO水平急剧升高;毛细支气管炎组、无喘息支气管肺炎组患儿在3个月后FeNO水平比正常儿童的FeNO水平高,差异均有统计学意义(P<0.05)。随访8个月失访6例(失访率为6.00%)。94例患儿中未发生喘息患儿43例(占45.74%),其中5次喘息2例(占2.13%)、4次喘息2例(占2.13%),3次喘息5例(占5.32%),2次喘息10例(占10.64%),1次喘息24例(占25.53%),与随访中12个月喘息发生次数呈正相关(r=0.834,P<0.05)。毛细支气管炎缓解期FeNO水平与喘息发生次数无相关性(r=0.187,P>0.05)。结论毛细支气管炎的发生可能与血嗜酸性粒细胞有关,且当毛细支气管炎患儿中FeNO的水平越低,发生喘息的可能性越高,因此,可通过测定FeNO的水平来判断对患儿的预后影响,在临床上具有一定的应用价值。
Objective To explore the clinical value of fractional exhaled nitric oxide(FeNO)detection in children with bronchiolitis.Methods 100 children with bronchiolitis(bronchiolitis group)who were hospitalized in the pediatric ward of NO.2 Women’s and Children’s Healthcare Hospital of Huizhou City from August 2018 to April 2019 were selected as the research subjects,and 50 healthy children with non-respiratory diseases(non-respiratory diseases group)and 50 cases of children with non-wheezing bronchopneumonia(non-wheezing bronchopneumonia group)of the same age and the same period undergoing examination were selected.The bronchiolitis group was given routine treatment.The FeNO levels were compared between non-respiratory diseases group,non-wheezing bronchopneumonia group and bronchiolitis group at the beginning of treatment and 3 months after treatment.Children with bronchiolitis were followed up for wheezing recurrence within 8 months.Results The FeNO level in the bronchiolitis group and the non-wheezing bronchopneumonia group was lower than that in the non-respiratory disease healthy group;The FeNO level in the bronchiolitis group after 3 months increased sharply compared with that at the beginning of treatment;the FeNO level in the bronchiolitis group and the non-wheezing bronchopneumonia group was higher than that in the normal children after 3 months,and the difference was statistically significant(P<0.05).During the 8-month follow-up,6 cases were withdrawn(lost rate was 6.00%).Of the 94 children,43 patients(45.74%)did not develop wheezing,including 2 cases of wheezing being 5 times(2.13%),2 cases being 4 times(2.13%),and 5 cases being 3 times(5.32%),10 cases being 2 times(10.64%),24 cases being once(25.53%),which was positively correlated with the number of wheezing occurred during 12 months of follow-up(r=0.834,P<0.05);there was no correlation between FeNO level in remission period and the number of wheezing occurrences(r=0.187,P>0.05).Conclusion The occurrence of bronchiolitis may be related to blood eosinophils and the lower the level of FeNO in children with bronchiolitis,the higher the possibility of wheezing.Therefore,the level of FeNO can be used to determine the prognosis of bronchiolitis children,which has a certain clinical application value.
作者
严晓宇
张南山
李芬田
YAN Xiaoyu;ZHANG Nanshan;LI Fentian(Huizhou No.2 Women's and Children's Healthcare Hospital,Guangdong,Huizhou 516000,China)
出处
《中国医药科学》
2020年第12期78-81,共4页
China Medicine And Pharmacy
基金
广东省惠州市医疗卫生类科技计划项目(2018Y137)。
关键词
呼出气一氧化氮
毛细支气管炎患儿
喘息
Fractional exhaled nitric oxide
Children with bronchiolitis
Wheezing
