摘要
目的分析糠酸莫米松鼻喷剂联合丙酸氟替卡松吸入治疗咳嗽变异性哮喘患儿的影响。方法选2017年2月~2019年10月我院收治的112例咳嗽变异性哮喘患儿为研究对象,采用随机数字表法分为参照组与试验组,各56例;对参照组患儿仅采用丙酸氟替卡松吸入治疗,试验组患儿采取糠酸莫米松鼻喷剂联合丙酸氟替卡松治疗;治疗后对比两组疗效、肺功能及呼出气一氧化氮(FeNO)水平。结果治疗前,两组患儿的咳嗽诊治积分、治疗总有效率、肺功能指标VC、FEV1、FEV1/FVC及PEFpred、FeNO水平比较,差异无统计学意义(P>0.05);治疗后,试验组患儿咳嗽诊治积分显著低于参照组,差异有统计学意义(P<0.05),且试验组患儿治疗总有效率、肺功能指标VC、FEV1、FEV1/FVC及PEFpred、FeNO水平均显著优于参照组,差异有统计学意义(P<0.05)。结论以糠酸莫米松鼻喷剂联合丙酸氟替卡松吸入针对咳嗽变异性哮喘患儿,能够有效缓解患儿的临床症状,其肺功能得到良好恢复,FeNO水平趋于正常,疗效较为显著,具有临床推广意义。
Objective To analyze the efficacy of mometasone furoate nasal spray combined with fluticasone propionate inhalation for children with cough variant asthma.Methods 112 children with cough variant asthma admitted to hospital from February 2017 to October 2019 were selected as the subjects and divided into the control group and experimental group through random number table method,with 56 cases in each group.The children in the control group were only treated with the therapy of fluticasone propionate inhalation,while the children in the experimental group were treated with mometasone furoate nasal spray combined with fluticasone propionate.After treatment,the curative efficacy,lung function and FeNO(fractional exhaled nitric oxide)level were compared between the two groups.Results Before treatment,there was no statistically significant difference in scores of cough diagnosis and treatment,total effective rate of treatment,pulmonary function indexes VC,FEV1,FEV1/FVC,and PEFpred and FeNO levels between the children of the two groups(P>0.05).After treatment,the scores of cough diagnosis and treatment of the children in the experimental group were significantly lower than those in the control group,with statistically significant difference(P<0.05),and the total effective rate of treatment,pulmonary function indexes VC,FEV1,FEV1/FVC,and PEFpred and FeNO levels of the children in the experimental group were significantly superior to those in the control group,with statistically significant difference(P<0.05).Conclusion The combination of mometasone furoate nasal spray and fluticasone propionate inhalation for children with cough variant asthma can effectively relieve the clinical symptoms of the children,bringing them sound recovery of lung function and gradual normalization of FeNO level.With significant curative efficacy,it is significant for clinical promotion.
作者
肖小兵
刁诗光
聂煜晢
邓建荣
陈道朋
XIAO Xiaobing;DIAO Shiguang;NIE Yuzhe;DENG Jianrong;CHEN Daopeng(Department of Pediatrics,Yue Bei People's Hospital Affiliated to Shantou University Medical College,Guangdong,Shaoguan 512026,China)
出处
《中国医药科学》
2020年第11期58-61,共4页
China Medicine And Pharmacy
基金
广东省韶关市卫生计生科研项目(Y18055)。
