摘要
沉默信息调节因子(Sirtuins)家族属于Ⅲ类组蛋白去乙酰化酶,具有高度保守的催化结构域。Sirtuins家族在癌症、心血管疾病、代谢性疾病及神经性疾病中发挥多种作用。近年研究发现,Sirtuins家族成员与动脉粥样硬化的发病机制密切相关。本文综述了其通过多种途径调节氧化应激、能量代谢、炎症反应等,从而延缓动脉粥样硬化的发生发展,以期为SIRT1-SIRT7作为动脉粥样硬化的治疗靶标提供依据和方向。
Sirtuins family is a classⅢhistone deacetylase of a highly conserved catalytic domain.Sirtuins family exerts effects on cancers,cardiovascular diseases,metabolic diseases and neurological diseases.Recent studies have found that Sirtuins members are closely related to the pathogenesis of atherosclerosis(As)by regulating the occurrence and development of As through diverse physiological mechanisms such as oxidative stress,energy metabolism and inflammatory response.We hope it provides evidence and direction for using SIRT1-SIRT7 as the target of As treatment.
作者
林蓉
郑子涵
LIN Rong;ZHENG Zihan(Department of Pharmacology, School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center, Xi'an 710061, China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2020年第3期309-316,共8页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
2018年国家自然科学基金资助项目(No.81770459)。
