摘要
目的 探讨估算的脉搏波传导速度(ePWV)与稳定性冠状动脉粥样硬化性心脏病(冠心病)患者主要不良心脏事件(MACE)发生的关系。方法 对Dryad开放数据库中一项关于稳定性冠心病研究数据进行二次分析,纳入原数据中所有稳定性冠心病患者。分别依据MACE发生情况与中位ePWV水平将研究对象分组,比较各组临床资料的差异。采用Cox比例风险回归模型分析ePWV与MACE的关系,运用ROC曲线评估ePWV对稳定性冠心病患者发生MACE的预测价值。结果 MACE组ePWV水平高于非MACE组(P=0.002),高ePWV组MACE发生率高于低ePWV组(P=0.042),差异均具有统计学意义。多因素Cox回归分析显示,ePWV与稳定性冠心病患者MACE独立相关(HR=1.380,95%CI:1.109~1.717,P=0.004)。ROC曲线显示,ePWV预测稳定性冠心病患者发生MACE的曲线下面积为0.677(P=0.003)。结论 ePWV与稳定性冠心病患者MACE独立相关,对稳定性冠心病患者发生MACE具有一定的预测价值。
Objective To explore the relationship between estimated pulse wave velocity(ePWV) and major adverse cardiac events(MACE) in patients with stable coronary artery disease.Methods Data extracted from a study on stable coronary artery disease in the Dryad database,an open access database,was selected for secondary analysis.All patients with stable coronary artery disease in the original data were included,and patients were divided into groups according to the occurrence of MACE and the median ePWV level,respectively.Cox proportional hazards models were used to analyze the relationship between ePWV and MACE.ROC curve was used to evaluate the predictive value of ePWV for MACE in patients with stable coronary artery disease.Results EPWV was significantly higher in patients with MACE than in those without MACE(P=0.002).The incidence of MACE was significantly higher in patients with high ePWV than in those with low ePWV(P=0.042).In multivariate Cox regression analysis,ePWV was independently associated with the MACE in patients with stable coronary artery disease(HR=1.380,95%CI:1.109~1.717,P=0.004).ROC curve analysis showed that the area under the ROC curve of ePWV to predict MACE in patients with stable coronary artery disease was 0.677(P=0.003).Conclusion EPWV is independently associated with the MACE in patients with stable coronary artery disease,and it could be used to predict the incidence of MACE in patients with stable coronary artery disease.
作者
张瑾
杨德爽
陶诗怡
陈颖
黄力
Zhang Jin;Yang Deshuang;Tao Shiyi;Chen Ying;Huang Li(Beijing University of Chinese Medicine,Beijing 100029,China;不详)
出处
《中国循证心血管医学杂志》
2022年第10期1237-1240,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
脉搏波传导速度
稳定性冠心病
不良心脏事件
Pulse wave velocity
Stable coronary artery disease
Adverse cardiac events
