摘要
目的分析N端脑钠肽在心力衰竭鉴别诊断及预后中的临床应用价值。方法选取2017年7～12月在我院进行医治的30例心力衰竭患者作为研究组,另选取同期在我院因气促而入院的患者为对照组,根据患者最终结局将研究组分为存活组(n=28)和死亡组(n=2)。统计比较研究组和对照组N端脑钠肽水平以及存活组和死亡组N端脑钠肽水平,比较存活组N端脑钠肽水平不同的患者因心脏不良事件再次住院的比率,分析N端脑钠肽水平在心衰组和非心衰组中的差异及与预后的关系。结果研究组N端脑钠肽水平较对照组高,两组比较差异具有统计学意义(P<0.01)。死亡组患者N端脑钠肽水平较存活组患者高,两组比较差异具有统计学意义(P<0.01)。随访6个月,存活组中出院时N端脑钠肽水平仍然升高的患者因心脏不良事件再次住院的比率(40.00%)较出院时N端脑钠肽水平正常的患者(5.56%)高,两组比较差异具有统计学意义(P<0.05)。结论心衰患者的N端脑钠肽水平较高,对于因慢性阻塞性肺病、哮喘癔症等非心衰患者的鉴别具有极高的鉴别意义,N端脑钠肽水平可以作为临床上鉴别心衰的诊断指标以及预后效果的评估依据。
Objective To analyze the clinical value of N-terminal brain natriuretic peptide in the differential diagnosis and prognosis of heart failure.Methods A total of 30 patients with heart failure who were treated in our hospital from July to December 2017 were enrolled as the study group.The patients who were admitted in our hospital because of shortness of breath in the same period were selected as the control group.According to the final outcome of the patients,the patients of the study group were the survival group(n=28)and the death group(n=2).The N-terminal brain natriuretic peptide levels in the study group and the control group,as well as the N-terminal brain natriuretic peptide levels in the survival group and the death group were compared.The ratio of patients with different N-terminal brain natriuretic peptide levels in the survival group re-hospitalization due to adverse cardiac events was compared.The difference in brain natriuretic peptide levels between heart failure group and non-heart failure group and its relationship with prognosis were analyzed.Results The level of N-terminal brain natriuretic peptide in the study group was higher than that in the control group.The difference between the two groups was statistically significant(P<0.01).The level of N-terminal brain natriuretic peptide in the death group was higher than that in the surviving group,and the difference between the two groups was statistically significant(P<0.01).During 6 months of follow-up,the rate of re-hospitalization of patients with elevated N-terminal brain natriuretic peptide levels at the time of discharge in the surviving group was 40.00%,higher than that of patients with normal N-terminal brain natriuretic peptide levels(5.56%)at discharge.The difference between the two groups was statistically significant(P<0.05).Conclusion The level of N-terminal brain natriuretic peptide in patients with heart failure is higher.It is highly distinguishable for the identification of patients with non-heart failure such as chronic obstructive pulmonary disease and asthmatic snoring.N-terminal brain natriuretic peptide level can be used as clinical identification and diagnostic indicators of aging and assessment of prognostic effects.
作者
刘涛
LIU Tao(Department of Cardiology,Ruijin People's Hospital in Jiangxi Province,Ruijin 342500,China)
出处
《中国现代医生》
2018年第36期6-8,12,共4页
China Modern Doctor
关键词
N端脑钠肽
心力衰竭
鉴别诊断
预后
N-terminal brain natriuretic peptide
Heart failure
Differential diagnosis
Prognosis
