摘要
目的探讨养胃舒颗粒联合L-谷氨酰胺呱仑酸钠颗粒治疗消化性溃疡的临床疗效。方法选取2017年3月—2018年3月在渭南市中医医院消化内科进行诊治的96例消化性溃疡患者,根据用药不同分为对照组和治疗组,每组各48例。对照组口服L-谷氨酰胺呱仑酸钠颗粒,0.67 g/次,3次/d。治疗组在对照组基础上口服养胃舒颗粒,10 g/次,2次/d。两组均经过4周治疗后进行效果评价。观察两组的临床疗效,比较两组治疗前后HP根除率、症状评分、血清学指标和胃肠激素水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别是81.25%、97.92%,对照组和治疗组的HP清除率分别是72.92%、91.67%,两组总有效率和HP清除率比较差异具有统计学意义(P<0.05)。治疗后,两组溃疡痛评分、腹胀评分、反酸嗳气评分均较治疗前显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组溃疡痛评分、腹胀评分、反酸嗳气评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清基质金属蛋白酶-9(MMP-9)、高迁移率族蛋白1(HMGB1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均显著降低,但VEGF显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组MMP-9、HMGB1、TNF-α、IL-6水平显著低于对照组,但血管内皮生长因子(VEGF)显著高于对照组,两组比较差异具有统计学意义(P<0.05)。两组血清肾上腺髓质素(AM)、胃泌素(GAS)水平均降低,而降钙素基因相关肽(CGRP)、生长抑素(SS)水平均显著增高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组AM、GAS低于对照组,但CGRP、SS高于对照组,两组比较差异具有统计学意义(P<0.05)。结论养胃舒颗粒联合L-谷氨酰胺呱仑酸钠颗粒治疗消化性溃疡可有效改善患者临床症状,降低机体炎症反应,改善胃肠激素水平,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Yangweishu Granules combined with L-Glutamine and Sodium Gualenate Granules in treatment of peptic ulcer. Methods Patients（96 cases） with peptic ulcer in Weinan Hospital of Traditional Chinese Medicine from February 2017 to January 2018 were divided into control（48 cases） and treatment（48 cases） groups according to the difference of treatment. Patients in the control group were po administered with L-Glutamine and Sodium Gualenate Granules, 0.67 g/time, three times daily. Patients in the treatment group were po administered with Yangweishu Granules on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy and HP clearance rates was evaluated, and the changes of HP eradication rate, symptom score, serologic indicators, and gastrointestinal hormone levels were compared. Results After treatment, the clinical efficacy in the control and treatment group were 72.92% and 91.67%, and HP clearance rates in the control and treatment groups were 72.92% and 91.67%, respectively, and there were differences between two groups（P 〈 0.05）. After treatment, ulcerative pain score, abdominal distension score, and acid regurgitation score in two groups were significantly decreased in two groups, and there were differences in the same group（P 〈 0.05）. After treatment, ulcerative pain score, abdominal distension score, and acid regurgitation score in the treatment group were lower than those in the control group, and there were differences between two groups（P 〈 0.05）. After treatment, MMP-9, HMGB1, TNF-α, and IL-6 were significantly decreased in two groups, but VEGF was significantly increased, and there were differences in the same group（P 〈 0.05）. After treatment, MMP-9, HMGB1, TNF-α, and IL-6 in the treatment group were lower than those in the control group, but VEGF was higher than those in the control group, and there were differences between two groups（P 〈 0.05）. After treatment, AM and GAS were significantly decreased in two groups, but CGRP and SS was significantly increased, and there were differences in the same group（P 〈 0.05）. After treatment, AM and GAS in the treatment group were lower than those in the control group, but CGRP and SS was higher than those in the control group, and there were differences between two groups（P 〈 0.05）. Conclusion Yangweishu Granules combined with L-Glutamine and Sodium Gualenate Granules can effectively improve the clinical symptoms, and can reduce the inflammatory response, also can improve the level of gastrointestinal hormones, which has a certain clinical application value.
作者
梁小燕
LIANG Xiao-yan(Department of Gastroenterology,Weinan Hospital of Traditional Chinese Medicine,Weinan 714000,China)
出处
《现代药物与临床》
CAS
2018年第10期2603-2607,共5页
Drugs & Clinic
