摘要
目的:观察针灸辅治消化性溃疡的疗效及血清肿瘤坏死因子(TNF-α)、白细胞介素-8(IL-8)、胃泌素水平变化。方法:选取2018年6月—2020年6月我院收治的消化性溃疡患者101例,根据数字表法将入选者分为对照组50例和观察组51例。2组均予以基础治疗,对照组加以常规西药治疗,观察组在对照组基础上实施针灸辅助治疗。比较2组短期(4周内)临床疗效,并记录其治疗前、治疗4周后的炎性因子[TNF-α、IL-8、热休克蛋白60(HSP60)]、血清胃肠功能指标[胃泌素(GAS)、生长抑素(SS)、胃动素(MTL)]、外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化及不良反应发生情况。结果:2组临床疗效分级比较发现,2组患者治疗4周后比较,差异有统计学意义(P<0.05),观察组总有效率为94.12%,对照组总有效率为80.00%,2组比较差异有统计学意义(P<0.05);2组患者治疗4周后IL-8、TNF-α、HSP60、GAS、MTL、CD8^(+)水平等6项指标较治疗前均显著下降,差异有统计学意义(P<0.05);而2组患者治疗后SS、CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)水平较治疗前均明显上升,差异有统计学意义(P<0.05),而观察组患者各项指标与对照组比较上升幅度较为明显,差异有统计学意义(P<0.05)。观察组患者总不良反应发生率为7.84%,对照组总发生率为12.00%,2组比较差异无统计学意义(χ2=0.853,P>0.05)。结论:对消化性溃疡患者行针灸辅助西药治疗有显著的治疗效果,通过降低致病性炎性因子,促进胃肠蠕动,同时能促进患者免疫系统恢复,值得临床推广应用。
Objective:To observe the curative effect of acupuncture and moxibustion in auxiliary treatment of peptic ulcer and the changes of serum tumor necrosis factor(TNF-α),interleukin-8(IL-8)and gastrin levels.Methods:A total of 101 patients with peptic ulcer who were admitted to our hospital from June 2018 to June 2020 were selected.According to the number table method,the selected patients were divided into 50 cases in the control group and 51 cases in the observation group.Both groups were given basic treatment,the control group was treated with conventional western medicine,and the observation group was given acupuncture and moxibustion on the basis of the control group.Compare the clinical efficacy of the two groups in the short term(within 4 weeks),and record the inflammatory factors(TNF-α,IL-8,heat shock protein)before and after 4 weeks of treatment.60(HSP60),serum gastrointestinal function indexes[gastrin(GAS),somatostatin(SS),motilin(MTL)],peripheral blood T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))changes and adverse reactions.Results:After 4 weeks of treatment,the clinical efficacy classification of the two groups was statistically significant(P<0.05),and the total effective rate of the observation group was 94.12%,which was significantly higher than the control group’s 80.00%(P<0.05);Treatment 4 Weeks later,the levels of IL-8,TNF-α,HSP60,GAS,MTL,and CD8^(+)in the two groups were significantly lower than before treatment(all P<0.05),while the levels of SS,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were all lower than before treatment.Increased(P<0.05),and the observation group changed more(P<0.05);during the treatment,the total incidence of adverse reactions in the observation group was 7.84%,while the control group was 12.00%,the comparison between the two groups was not statistically significant(χ2=0.853,P>0.05).Conclusion:Acupuncture and moxibustion assisted western medicine has a significant effect on peptic ulcer,which can reduce inflammatory factors and promote gastrointestinal motility,and is beneficial to the recovery of its immune function.It is worthy of promotion.
作者
周立基
王广发
ZHOU Liji;WANG Guangfa(ICU of Beijing Wangfu Integrated Chinese and Western Medicine Hospital,Beijing,100000,China;Respiratory Medicine of Beijing Civil Aviation General Hospital)
出处
《中国中西医结合消化杂志》
CAS
2022年第1期21-25,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
针灸
消化性溃疡
疗效
胃泌素
免疫功能
白细胞介素-8
acupuncture and moxibustion
peptic ulcers
efficacy
gastrin
immune function
interleukin-8
