摘要
目的探究食管癌患者外周血T淋巴细胞亚群水平变化及临床意义。方法以在我院接受治疗的食管癌患者60例为食管癌组,以同期在我院接受体检的健康人群50例为健康组。对比两组外周血T淋巴细胞亚群水平及食管癌组不同TNM分期外周血T淋巴细胞亚群水平。结果食管癌组患者CD3^+、CD4^+、CD4^+/CD8^+水平显著低于健康组(P<0.05),两组CD8^+水平差异不显著(P>0.05);食管癌Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者CD3^+、CD4^+、CD4^+/CD8^+水平依次降低(P<0.05),四期CD8+水平差异不显著(P>0.05)。结论食管癌患者免疫功能被抑制,且随着病情的发展免疫功能抑制越严重,可为分期诊断提供依据。
Objective To investigate the changes and clinical significance of T lymphocyte subsets in peripheral blood of patients with esophageal cancer. Methods A total of 60 esophageal cancer patients treated in our hospital were recorded as esophageal cancer group, and another 50 healthy subjects undergoing physical examination in our hospital during the same period were selected as health group. The levels of T lymphocyte subsets in peripheral blood of the two groups and the T lymphocyte subsets of peripheral blood in different TNM stages of esophageal cancer group were compared. Results The levels of CD3^＋, CD4^＋ and CD4^＋/CD8^＋ in the esophageal cancer group were significantly lower than those in the healthy group（P〈0.05）, while there was no significant difference in the levels of CD8^＋ between the two groups（P〉0.05）. The levels of CD3^＋, CD4^＋ and CD4^＋/CD8^＋ in stage Ⅰ,Ⅱ,Ⅲ,Ⅳ decreased in turn（P〈0.05）, while there was no significant difference in the levels CD8^＋ among the four stages（P〉0.05）. Conclusion The immune function of patients with esophageal cancer is inhibited,and the inhibition of immune function is more serious with the development of the disease. It can provide the basis for staging diagnosis.
作者
王登峰
雷利强
WANG Deng-feng;LEI Li-qiang(Clinical Laboratory, Baoji Central Hospital, Baoji 721008;Clinical Laboratory, Traditional Chinese Medicine Hospital of Baoji,Baoji 721001, China)
出处
《临床医学研究与实践》
2018年第14期91-92,共2页
Clinical Research and Practice
关键词
食管癌
T淋巴细胞亚群
免疫功能
esophageal cancer
T lymphocyte subsets
immune function
