摘要
目的:探讨放疗对食管鳞癌患者血清鳞状上皮细胞癌抗原(squamous cell cancer,SCC)、癌胚抗原(carcinoembryonic antigen,CEA)、细胞角蛋白19片段抗原21-1(cytokerantin-19-fragment antigen21-1,CRFRA21-1)、肿瘤相关糖蛋白72(tumor associated glycoprotein,TAG72)、糖类抗原199(cancer antigen 199,CA199)水平及T淋巴细胞亚群的影响。方法:选择2013年1月~2016年1月在江阴市人民医院确诊的60例食管鳞癌患者为实验组,另外同期选择40例健康体检者为对照组。实验组患者给予6MV X线放射治疗。检测并比较实验组患者放疗前和放疗后1个月、对照组健康者血清SCC、CEA、CRFRA21-1、TAG72、CA199水平及外周血CD4+、CD8+细胞所占的比值。结果:治疗前,实验组患者血清SCC、CEA、CRFRA21-1水平均明显高于对照组健康者,差异具有统计学意义(均P<0.05);治疗后,实验组患者血清SCC、CEA、CRFRA21-1水平均明显低于治疗前,但实验组患者上述各肿瘤标志物水平均明显高于对照组健康者,差异具有统计学意义(均P<0.05)。治疗前,实验组患者外周血CD4^+、CD4^+/CD8^+所占比值明显低于对照组健康者,CD8^+细胞所占比值明显高于对照组健康者,差异具有统计学意义(均P<0.05);治疗后,实验组患者外周血CD4^+、CD8^+细胞所占比值及CD4^+/CD8^+比值与治疗前比较差异无统计学意义(均P>0.05),且实验组患者外周血CD4^+、CD4^+/CD8^+细胞所占比值明显低于对照组健康者,CD8^+比值明显高于对照组健康者,差异具有统计学意义(均P<0.05)。结论:放疗能明显降低食管鳞癌患者血清SCC、CEA、CRFRA21-1、水平,但对T淋巴细胞亚群水平影响不明显。
[ABSTRACT]Objective：To study the effect of radiotherapy on serum SCC,CEA,CRFRA21-1,TAG72,CA1 99 and lymphocyte subsets in patients with esophageal squamous cell carcinoma.Methods：A total of 60 patients with esophageal squa-mous cell carcinoma in our hospital from January 2013 to January 201 6 were selected as experiment group and 40 healthy sub-jects were selected as control group.Patients in experiment group were treated with 6MV X-ray radiation therapy.Serum SCC, CEA,CRFRA21-1,TAG72,CA1 99 and the cell percentage of peripheral blood CD4 ＋ ,CD8 ＋ were compared in control group and the experimental group before and after 1 month radiotherapy.Results：Before treatment,the levels of serum SCC,CEA and CRFRA21-1 in the experimental group were significantly higher than those in the control group （P 〈0.05 ）;After treat-ment,the levels of serum SCC,CEA and CRFRA21-1 in the experimental group were significantly lower than those before treatment,but the experimental group patients were significantly higher than those in the control group （P 〈0.05）;There was no significant difference between the experimental group and the control group in the level of serum TAG72 and CA1 99 before treatment,and there was no significant difference in the serum levels of TAG72 and CA1 99 before and after radiotherapy in the experimental group （P 〉0.05）.Before treatment,the cell percentage of peripheral blood CD4 ＋ ,CD8 ＋ and the ratio of CD4 ＋/CD8 ＋ in experimental group was significantly lower than that of the control group,the percentage of peripheral blood CD8 ＋ in the experimental group was significantly higher than that in the control group （P 〈0.05 ）;Compared with before treatment, there was no statistically significant difference after treatment in the cell percentage of peripheral blood CD4 ＋ ,CD8 ＋ and the ratio of CD4 ＋/CD8 ＋ in experimental group （P 〉0.05）,and in the experimental group,the proportion of CD4 ＋ cells and the tatio of CD4 ＋/CD8 ＋ in peripheral blood was significantly lower than that of the control group,the proportion of CD8 ＋ was significantly higher than that of the control group （P 〈0.05 ）.Conclusions：Radiotherapy can significantly reduce the serum SCC,CEA,CRFRA21-1,TAG72 and CA1 99 levels of the patients with esophageal squamous cell carcinoma,but have less in-fluence on the T lymphocyte subsets.
出处
《海南医学院学报》
CAS
2016年第17期2003-2006,2010,共5页
Journal of Hainan Medical University
基金
江苏省卫生厅重点学科省内开放课题(KG2014199)~~
