摘要
固有淋巴细胞(innate lymphoid cells,ILCs)是近年来的研究热点,它们在体内广泛分布,在不同组织发挥重要的作用。其中淋巴组织诱导细胞(lymphoid tissue-inducer cell,LTi)和其他新近发现的三型固有淋巴细胞主要分布在肠道固有层,在肠道抗感染免疫、维持肠道稳态以及自身免疫病中发挥重要作用,进一步揭开了固有淋巴细胞的神秘面纱。
Innate lymphoid cells （ILCs） have been researched extensively in recent years. It is now dear that ILCs populate almost every tissue and have important roles. Lymphoid tissue-inducer cell and other newly found ILC3 subgroups, which are distributed mainly in the intestinal lamina propria, proved to play important roles in defense against infectious intestinal diseases, maintaining tissue homeostasis and regulating autoimmune diseases. These further indicate the importance of ILCs.
作者
卢晨雨
汪洌
LU Chen-yu;WANG Lie(Institute of Infection and Immunity, School of Basic Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China)
出处
《生命科学研究》
CAS
CSCD
2018年第2期167-172,共6页
Life Science Research
基金
国家自然科学基金重大研究计划(91442101)
关键词
固有淋巴细胞(ILCs)
发育
肠道感染
肠道稳态
自身免疫病
肿瘤
innate lymphoid cells （ILCs）
development
intestinal infection
intestinal homeostasis
autoimmune disease
tumor
