摘要
MicroRNA是一类数量庞大且高度保守的非编码小RNA，在转录后水平通过翻译抑制或介导靶蛋白降解来调控基因的表达，在细胞凋亡、免疫应答、肿瘤发生及营养代谢等生物学过程中扮演着重要角色。肠上皮屏障是维持机体正常生命活动的第一道防线，其完整性在维持肠道黏膜屏障功能及肠道稳态中起着至关重要的作用。该文将对miRNA的生物学作用及其对肠上皮屏障的基本构成的调控作用作一综述。
MicroRNAs are a group of large and highly conserved non-coding small stranded RNAs that regulate the gene expression by translational inhibition or mediated degradation of target proteins at post-tran- scriptional levels, which plays an important role in many biological processes, including cell apoptosis, immune response,tumorigenesis and nutritional metabolism. The intestinal epithelial barrier is the first defense to maintain the general physiological phenomenon, and its integrity is a critical factor of the maintenance of intestinal muco- sal barrier function and intestinal homeostasis. This article reviews the biological function of miRNAsand their post-transcriptional regulation of the formation of intestinal epithelial barrier.
作者
杨丽娟
许玲芬
Yang Lijuan ,Xu Lingfen(Department of Pediatric Gastroenterology , Shengjing Hospital of China Medical University, Shenyang 110004, Chin)
出处
《国际儿科学杂志》
2018年第3期184-187,共4页
International Journal of Pediatrics
基金
国家自然科学基金青年基金（81400585）
辽宁省自然科学基金（2014021042）
