摘要
目的探索hs-CRP、PCT以及CD4^+CD25^+ Treg细胞比率在诊断肺炎合并脓毒血症过程中的临床应用效果与价值。方法本研究采用回顾性病例对照研究方法,收集本院诊断为肺炎合并脓毒血症的患儿45例为肺炎合并脓毒血症组,对照组选择本院中其他疾病患者50例。结果肺炎合并脓毒血症组PCT、hs-CRP和CD4^+CD25^+ Treg(%)细胞水平均高于对照组,差异有统计学意义(t值分别为35.71、19.85、21.39,P均<0.01)。hs-CRP、PCT和CD4^+CD25^+ Treg细胞的ROC曲线下面积分别为0.871、0.840和0.812,3者之间差异无统计学意义(P>0.05)。hs-CRP、PCT和CD4^+CD25^+ Treg细胞在肺炎合并脓毒血症的诊断最佳截点分别是≥12.4 mg/L、≥2.08 ng/ml和≥6.87%。结论CD4^+CD25^+ Treg细胞比率可能是诊断肺炎合并脓毒血症新的诊断指标,具有良好的临床诊断价值。
Objective To assess the efficacy and value of hs-CRP,PCT and CD4^＋CD25^＋ Treg cell ratios for the differentiation between patients with and without pneumonia and sepsis. Methods Retrospective case-control study method was used to collected data in our hospital. 45 cases diagnosed as pneumonia and sepsis were enrolled in the pneumonia and sepsis group,and 50 other patients having no similar disease like sepsis in our hospital were enrolled in the control group. Results The levels of PCT,hs-CRP and CD4^＋CD25^＋ Treg（ %） in the pneumonia and sepsis group were higher than those in the control group,and the differences were statistically significant（ t = 35. 71,t = 19. 85,t = 21. 39,P〈0. 01）. The area under ROC curve of hs-CRP,PCT and CD4^＋CD25^＋ Treg was 0. 871,0. 840 and 0. 812,and the differences of three of them were not statistically signifiant（ P〉0. 05）. The cut-off point of hs-CRP,PCT and CD4^＋CD25^＋ Treg cells for diagnosis of sepsis complicated with pneumonia were ≥12. 4 mg/L,2. 08 ng/m L and 6. 87%. Conclusion The ratio of CD4^＋CD25^＋ Treg cells may be a new diagnostic index for the diagnosis of pneumonia complicated with sepsis,and has a good clinical diagnostic value.
出处
《中国卫生检验杂志》
CAS
2017年第20期2941-2943,共3页
Chinese Journal of Health Laboratory Technology
基金
邯郸市科学技术研究与发展计划(1623208095ZC)
