摘要
目的 探讨中性粒细胞CD64、Hs-CRP、PCT检测在新生儿败血症早期诊断中的价值.方法 选取2011年1月～2013年1月收治的新生儿败血症患者98例作为观察组,同时选取同期98例健康新生儿作为对照组,对两组的中性粒细胞CD64的表达水平、Hs-CRP水平、PCT水平以及阳性率进行比较,并对3项指标联合检测以及单独检测的特异性、敏感性、阳性预测值和阴性预测值进行比较分析.结果 观察组中性粒细胞CD64的表达水平、血清Hs-CRP、PCT水平以及阳性率与对照组比较均明显升高,差异均有统计学意义（均P＜0.05）;3项指标进行联合检测的特异度及阳性预测值均明显高于单用CD64、Hs-CRP、PCT检测,差异均有统计学意义（均P＜0.05）.结论 中性粒细胞CD64、Hs-CRP、PCT检测在新生儿败血症患者的早期诊断中具有较高的临床应用价值,且3项指标联合检测更有利于患儿早期诊断率的提高,能够作为新生儿败血症治疗效果的判断依据,值得在临床推广应用。
Objective To explore the value of the early diagnosis of the Neutrophil CD64, Hs-CRP and PCT about the neonatal sepsis. Methods 98 patients with neonatal sepsis were selected as the observation group and another 98 healthy newborn as the control group. The level of the Neutrophil CD64, Hs-CRP, PCT, the rate of positive were ob- served. The specificity, sensitivity, positive predictive value and negative predictive value of the combination or the single of the three indicators were analyzed. Results Compared with the control group, we could find out that the levels of the Neutrophil CD64, Hs-CRP, PCT and the rate of the positive about the observation group were obviously higher than that of control group （P〈0.05）. The specific and positive predictive value of the joint detection of the three indicators were obvious higher than that of the single detection （P〈0. 05）. Conclusion Early diagnosis of the Neutrophil CD64, Hs- CRP and PCT about the neonatal sepsis has high clinical value, and the application of joint detection of the three indica- tors is more conducive to children improve early diagnosis rate.
出处
《西部医学》
2015年第5期768-770,共3页
Medical Journal of West China
