摘要
目的探讨高危型人乳头状瘤病毒(HPV)感染与宫颈病变的关系。方法抽取2015年1~12月在大连市瓦房店妇幼保健院采用HPV检测进行宫颈癌初筛的9672例作为研究对象,分析高危型HPV感染与宫颈病变的关系。结果 HPV阴性8741例,阳性931例,24例为宫颈活检低级别病变,93例宫颈高级别病变,1例高级别病变可疑浸润癌,1例宫颈鳞癌。HPV检测阳性组学历及患阴道炎率明显高于HPV阴性组,差异有统计学意义(P<0.01)。HPV16、18和52型最容易引起宫颈病变。结论高危型HPV感染与宫颈癌前病变及宫颈癌的关系较为密切,在高危型HPV感染中,HPV16、18和52型为主要的感染因素。高危型HPV感染检测对宫颈癌筛查具有诊断意义。
Objective To investigate the relationship between high-risk HPV infection and cervical lesions.Methods A total of 967：2 patients with cervical cancer who were screened by HPV method in Dalian Wafangdian Women and Children＇s Hospital from January to December in 2015 were selected as research subjects,and the relationship between high-risk HPV infection and cervical lesions was analyzed.Results 8741 cases were HPV negative,and 931 cases were HPV positive.24 cases were low-grade lesions diagnosed by cervical biopsy,93 cases were cervical high-grade lesions, 1 case was high-grade lesion with suspected invasive carcinoma,and 1 case was cervical squamous cell carcinoma;the educational background and incidence rate of vaginitis in patients with HPV positive were significantly higher than those in patients with HPV negative,and the differences were significant （P〈0.01）.HPV 16,18 and 52 were most likely to cause cervical lesions.Conclusion There is a close relationship between high-risk HPV infection and cervical precancerous lesions and cervical cancer.HPV 16,18 and 52 are the main infection factors in the high-risk HPV infection. Test of high-risk HPV infection has diagnostic significance in the screening of cervical cancer.
出处
《中国当代医药》
2017年第3期86-88,100,共4页
China Modern Medicine
