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人乳头瘤病毒16型E5蛋白的生物学活性研究进展 被引量：12

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摘要 宫颈癌发病率位于女性肿瘤的第3位,全球每年有约27万女性死于宫颈癌。人乳头瘤病毒（human papilloma virus,HPV）持续感染是宫颈癌的主要危险因素,90%以上的宫颈癌伴有高危型HPV感染。HPV是一种乳头瘤空泡病毒,为球形DNA病毒,能引起皮肤黏膜的鳞状上皮增殖。目前已分离出130多种HPV,根据其致癌危险性不同可分为低危型（low-risk human papilloma virus,LR-HPV）和高危型（high-risk human papilloma virus，HR-HPV）两大类。
作者 杨慧伦 张宗峰
机构地区 哈尔滨医科大学附属二院妇科肿瘤科
出处 《疑难病杂志》 CAS 2015年第10期1084-1087,共4页 Chinese Journal of Difficult and Complicated Cases
基金 黑龙江省自然科学基金面上项目(No.200906) 黑龙江省卫生厅科研课题(No.2009-112) 哈尔滨医科大学附属二院博士科研基金项目(No.BS2009-15)
关键词 人乳头瘤病毒16型 E5蛋白 生物学活性 宫颈癌
分类号 R737.33 [医药卫生—肿瘤]
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参考文献24

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  • 4潘登华,何融泉,韦康来,陈罡.人乳头状病毒E6蛋白与宫颈癌关系的研究进展[J].医学研究生学报,2014,27(11):1229-1232. 被引量：14
  • 5于宇,张淑兰.HPV16E5蛋白在宫颈癌发生中的作用[J].国际妇产科学杂志,2014,41(1):39-42. 被引量：5
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二级参考文献113

  • 1吕秀宁,郑杰.三氧化二砷诱导HeLa细胞凋亡与其抑制HPV18 E6表达和端粒酶活性有关[J].中华肿瘤杂志,2005,27(5):265-268. 被引量：16
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  • 10Welters M J P, Kenter G G, Piersma S J, et al. Induction of tumor-specific CD4 + and CD8 + T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine. Clinical Cancer Research, 2008, 14: 178-187.

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疑难病杂志
2015年 第10期

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