摘要
目的 :检测食管癌组织中表皮生长因子受体家族的表达水平 ,了解其与食管癌临床病理各指标及预后的关系。方法 :采用免疫组化的方法检测 10例正常食管组织和 4 5例食管癌切除术后患者肿瘤组织中EGFR家族的表达情况。结果 :EGFR、HER2和HER4在食管癌组织中存在过度表达现象。EGFR家族过度表达与食管癌常见致病因素和肿瘤分化程度无关。随着食管癌局部浸润程度的加重 ,EGFR过度表达率增高。在淋巴结转移组中 ,EGFR的过度表达、EGFR +HER2和EGFR +HER4以及EGFR、HER2和HER4三者的联合过度表达明显增加 (P <0 .0 5 )。EGFR和HER4的过度表达以及成员间联合过度表达提示较差的预后。结论 :食管癌中存在EGFR家族的过度表达及联合过度表达。EGFR家族的过度表达与肿瘤局部浸润和淋巴结转移相关。表皮生长因子受体家族过度表达提示预后不佳。而联合过度表达在食管癌的预后判断上可能更有意义。
Objective: To investigate the expression of EGFR family in esophageal carcinoma and its relation with clinical significance. Methods: We detected the expression of EGFR family in 10 cases of normal esophageal mucosa and 45 cases of esophageal carcinoma by means of immunohistochemistry. Results: Overexpression of EGFR?HER2 and HER4 was present in esophageal carcinoma. There was no correlation between overexpression of EGFR family and most common etiological factor,nor tumor differentiation. The rate of EGFR overexpression increased along with the depth of local invasion. In patients with lymph node metastasis, the overexpression of EGFR? HER2? HER4 and co-overexpression of EGFR+HER2, EGFR+HER4, HER2+HER4, EGFR+HER2+HER4 obviously increased (P<0.05). Patients with EGFR or HER4 overexpression or co-overexpression among the EGFR members have worse prognosis. Conclusion:Overexpression and co-overexpression of EGFR family were common in esophageal carcinoma. There was a correlation between EGFR family overexpression and local invasion of tumor as well as the lymph nodes metastasis. Overexpression of EGFR family suggested a worse prognosis. Co-overexpression of EGFR members might be more meaningful in judgement of prognosis of esophageal carcinoma.
出处
《中国临床医学》
2004年第5期717-720,共4页
Chinese Journal of Clinical Medicine
