摘要
目的：研究程序性细胞死亡因子5（PDCD5）与AT丰富结构域IA（ARID1A）在结直肠癌（CRC）中的表达。方法：应用免疫组织化学法检测结直肠癌（55例）、结直肠腺瘤（18例）和结直肠黏膜慢性炎症（18例）组织中PDCD5与ARID1A的表达，同时，分析PDCD5及ARID1A蛋白的表达与CRC患者淋巴结转移、生存期及TNM分期的关系，采用spearman’s方法分析结直肠癌组织中PDCD5及ARID1A蛋白表达的相关性；随访CRC患者1～60个月，分析PDCD5及ARIDIA蛋白表达阳性或阴性CRC患者的生存曲线图。结果：在结直肠癌、结直肠腺瘤、结直肠黏膜慢性炎症组织中，PDCD5的阳性表达率分别为45．5％（25／55）、83．3％（15／18）和94．4％（17／18），差异有统计学意义（P〈0．05）；ARID1A阳性表达率分别为52．5％（29／55）、80％（14／18）和100％（18／18），差异有统计学意义（P〈0．05）；CRC患者组织中PDCD5与ARID1A呈正相关（r=0．279，P=0．039）；AR—ID1A的表达与TNM分期、淋巴结转移及5年生存期有关（P〈0．05）；结直肠癌中PDCD5、ARID1A阳性表达病例的生存状况较阴性病例好。结论：PDCD5、ARID1A的表达对结直肠癌的发生发展有一定的影响。
Objective： To study the clinical significance of programmed cell death factor （PDCD5） and AT rich interactive domain 1A （ ARID 1 A） expression in colorectaI carcinoma （CRC）. Methods ： PDCD5 and ARID 1A expression in 55 cases of CRC, 18 cases of colorectal adenoma, 18 cases color- ectal inflammation were determined by immunohistochemistry. At the same time, the correlation of PD- CD5 and ARID1A expression in CRC patients with lymph node metastasis , survival period and TNM staging was studied, and the correlation between PDCD5 and ARIDIA protein expression in colorectal cancer tissues was analyzed by spearman＇s method ; CRC patients were followed up for 1 to 60 months to study survival curve of CRC patients with ARIDI A and PDCD5 protein positive or negative expres- sion. Results： In CRC, colorectal adenoma and colorectal inflammation , the positive expression rate of PDCD5 was 45.5% （25/55）, 83.3% （ 15/18 ）, 94.4% （ 17/18 ） respectively with significant differ- ences among them （P 〈 0.05） ; the ARID 1A positive expression rate was 52.5% （29/55）, 80% （ 14/18 ）, 100% （ 18/18 ） respectively with significant differences among them （ P 〈 0.05 ） ; ARID 1 Awas positively correlated with PDCD5 （r = 0. 279 ,P = 0.039 ）in CRC patients; ARID 1A expression in colorectal cancer tissues was associated with TNM staging, lymph node metastasis and 5 years survival （P 〈 0.05 ） ; living condition of the ARID1A and PDCD5 positive expression CRC cases were better than the negative cases. Conclusion： ARID1A and PDCD5 expression has a certain effect on the oc- currence and development of colorectal cancer.
出处
《贵阳医学院学报》
CAS
2016年第6期696-699,共4页
Journal of Guiyang Medical College
基金
贵州省科技厅基金(E2010-4)
