摘要
目的:探索在适形调强放疗(IMRT)剂量验证中应用三维探测器ArcCheck替代二维探测器PTW729的可行性和优越性,分析影响PTW729、ArcCheck进行IMRT计划剂量验证通过率的主要因素。方法:分别使用ArcCheck和PTW729对IMRT计划进行验证测量,基于不同标准参数进行Gamma分析,采用两两比较的配对t检验对相同标准参数下的两种验证工具的γ通过率进行统计学分析,再利用非线性拟合的方法分析不同标准参数对两种工具验证结果的影响。结果:在临床常用标准参数下(剂量偏差>2%,距离偏差>2 mm,TH10),ArcCheck与PTW729对IMRT计划的剂量验证结果差异无统计学意义(P>0.05);影响上述两种验证工具γ通过率的主要因素分别是剂量偏差和距离偏差。结论:在临床常用标准参数范围内,三维验证系统ArcCheck是一种理想的IMRT剂量验证工具,其验证结果能更全面准确地反映实际治疗的各种信息。
Objective To explore the feasibility and superiority of applying three-dimensional detector ArcCheck to replace two-dimensional detector PTW729 in the dose verification of intensity-modulated radiotherapy; to analyze the main factors influencing the Gamma pass rates of intensity modulated radiotherapy（IMRT） plans based on PTW729 and ArcCheck.Methods ArcCheck and PTW729 were respectively applied to verify and measure the IMRT plans. Based on the Gamma analysis with different standard parameters, the Gamma pass rates of the two verification methods with the same standard parameters were compared by using the paired t-test. The non-linear fitting method was used to discuss on the effects of different standard parameters on the verification results of two methods. Results Based on the usual clinical standard parameters（dose deviation is greater than 2%; distance deviation is greater than 2 mm; threshold parameter is 10）, the verification results of PTW729 and ArcCheck didn＇t show any statistical differences（P0.05）. The dose deviation and distance deviation were the main factors influencing Gamma pass rates of IMRT plans. Conclusion Within the range of usual clinical parameters, three-dimensional system ArcCheck is an ideal tool for the dose verification of IMRT plans, and the results reflect the information of actual treatment more comprehensively and accurately.
出处
《中国医学物理学杂志》
CSCD
2016年第5期473-477,共5页
Chinese Journal of Medical Physics
基金
安徽省高校省级自然科学研究项目(KJ2010B380)
