摘要
目的:研究18F-脱氧葡萄糖(FDG)PET/CT显像对甲状腺显影病变性质分析及最大标准摄取值(SUVmax)与甲状腺良恶性病变的相关性。方法:收集从2011年6月至2013年12月中来我科行18F-FDG PET/CT全身显像中甲状腺弥漫性及局灶性摄取病人共113例,所有病例最终诊断依靠甲状腺细针穿刺、手术病理、甲功五项及6个月随访观察证实,并进行良恶性病灶相关性分析。结果:甲状腺单侧或双侧弥漫性显影病人34例,其中甲状腺功能亢进2例,原发性甲状腺淋巴瘤3例,淋巴瘤累及甲状腺1例,1例为亚急性甲状腺炎,桥本氏甲状腺炎27例,良恶性比例为7.5∶1;甲状腺局灶性显影79例,其中良性病变46例,恶性病变33例,恶性比例为41.7%。良恶性结节SUVmax有明显统计学意义,分别为(4.47±1.37与7.07±1.22,t=8.702,P<0.05)。结论 :18F-FDG PET/CT显像中甲状腺弥漫性显影以良性病变为主,且多为甲状腺炎症,;局灶性甲状腺显影中,虽甲状腺恶性病变比例较高,但单存的SUV值无法鉴别其良恶性。在良恶性结节SUVmax值比较中,SUVmax值越高,其恶性可能性越大。
Objective To evaluate the value of increased thyroid gland uptake and the clinical significance of SUVmax in distinguishing thyroid benign diseases from malignant diseases via 18F-FDG PET/CT. Methods：113 cases with focal or diffuse FDG uptake in thyroid were collected and retrospectively analyzed. Final diagnosis of all cases based on fine-needle aspiration,surgical operation, measurement of thyroid hormone, and 6 months follow-up studies. The data were correlatively analysed. Results There were 34 patients with unilateral or bilateral diffuse thyroid imaging,including 2 cases of hyperthyroidism, 3 cases of primary thyroid lymphoma,1 case of secondary thyroid lymphoma, 1 case of subacute thyroiditis,and 27 cases of Hashimoto disease. The ratio of benign to malignant was 7.5：1. Of the 79 patients with focal thyroid imaging,46 cases were benign and 33 were maglinant, maglinant lesions accounted for 41.7%. The SUVmax of benign and malignant thyroid nodules were 4.47±1.37 and 7.07±1.22,respectively,having statistical difference（P〈0.05）. ConclusionThe diffuse thy-roid uptake mostly indicates benign thyroid disease, most of which are thyroid inflammation. Although lesion with focal uptake is more likely to be malignant. However, SUVmax alone cannot discrimate the malignancy. In comparison of the value of benign and maglinant lesion, the higher the value of SUVmax,the greater possibility of malignance is.
出处
《泸州医学院学报》
2015年第4期364-367,共4页
Journal of Luzhou Medical College
基金
四川省科技厅-泸州市政府-泸州医学院联合科研专项资金项目(编号:14ZC0062)
