摘要
道地药材具有特异性、地域性特点,其独特的表型特征与药用植物的生长发育有着密切的关系。除经典遗传之外,表观遗传现象在药材道地性形成中发挥重要作用。该文介绍了表观遗传的范畴以及DNA甲基化在基因表达调控中的作用,并从道地药材特异性表型、地域性形成特征入手,展望表观遗传在药材道地性形成机制研究中的前景,为道地药材质量评价和鉴别提供依据。
Dao-di Herbs is specificity and locality, and its unique phenotypic features is closely related to the growth and develop- ment of medicinal plants. In addition to traditional genetic, epigenetic play an important role in formation of Dao-di herbs. This paper introduces the concept of epigenetic and the role of DNA methylation in the gene expression regulation. We further prospects epigenetic mechanism in study of Dao-di herbs formation from specific phenotype and regional analysis. And study on the relationship of epigenetic and Dao-di herbs will provide a basis for quality＇ assessment and identification of Chinese drugs.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第13期2679-2683,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81373959)
国家高技术研究发展计划(863)项目(SS2014AA022201)
科技基础性工作专项(2015FY111500)
中医药行业科研专项(201407003)
