摘要
组蛋白甲基化是表观遗传调节模式中一种重要修饰方式,易受环境影响,对调控次生代谢产物生物合成具有一定作用。本文论述了组蛋白甲基化修饰的基本概念与转录调控机制,探讨了其通过不同方式调控次生代谢产物的生物合成,同时也阐明了组蛋白甲基化与其他组蛋白修饰协同调控次生代谢产物合成,旨在为构建以组蛋白甲基化为切入点,以转录调控为桥梁,以次生代谢产物为重点的药用植物次生代谢产物形成分子机制研究平台提供理论依据。
Histone methylation is an important way of epigenetic regulation, and it has vulnerability to en- vironmental factors and has certain effects to regulate the biosynthesis of secondary metabolites. The paper discusses the concept of histone methylation and the mechanism of transcriptional regulation, exploring the different ways of regulating secondary metabolites synthesis, and clarifying the histone methylation and other histone modifications to regulate the synthesis of secondary metabolites, as well. We aims at providing the theoretical foundation for constructing research platform about the molecular mechanisms of secondary me- tabolite formation in medicinal plants, on which deems histone methylation as pointcut, regards transcriptional regulation as bridge and considers secondary metabolites as key.
出处
《生命的化学》
CAS
CSCD
2016年第4期431-436,共6页
Chemistry of Life
基金
国家自然科学基金项目(81373959)
中医药行业科研专项(201407003)
关键词
组蛋白甲基化
转录调控
次生代谢产物
histone methylation
transcriptional regulation
secondary metabolites
