摘要
目的探讨外周动脉粥样硬化病(PAD)风险分级与血浆β2-微球蛋白(β2-microglobulin,β2-MG)、高敏C反应蛋白(high-sensitivity C-reactive protein H-CRP)和同型半胱氨酸(homocysteine,HCY)关系。方法对沧州市人民医院普外(血管外科)2010年1月至2013年5月诊治的PAD患者96例进行分级。按ABI值分为:低风险组(0.7≤ABI≤0.9,n=25),中风险组(0.4≤ABI<0.7,n=52)和高风险组(ABI<0.4,n=19)。均以同期40例健康者作为对照,比较各组的β2-MG、H-CRP、HCY的浓度,进行相关性分析。结果血清β2-MG、H-CRP、HCY的浓度随着ABI分期的进展而升高,ABI的数值与β2-MG、H-CRP、HCY的浓度呈负相关(P<0.05)。结论 PAD随着病情的严重程度,血浆中的β2-MG、H-CRP、HCY浓度逐渐升高;β2-MG、H-CRP和HCY联合测定与ABI分级结合有助于更好地判断PAD患者的诊断和预后。
Objective To investigate the peripheral atherosclerotic disease （PAD） risk classiifcation and plasmaβ2-microglobulin （β2-microglobulin, β2-MG） high-sensitivity C-reactive protein （H-CRP） of homocysteine （HCY） relationship. Methods From January, 2010 to May, 2013 96 PAD patients were graded and treated in our hospital. According to the ABI value they were divided into： low risk group （0.7≤ABI≤0.9, n=25）, medium risk group （0.4≤ABI 〈 0.7, n=52）, and the high risk group （ABI 〈 0.4, n=19）. 40 healthy persons served as the controls the concentration of β2-microglobulin, high CRP, HCY and their correlation were analyzed. Results The concentration of serumβ2-MG, H-CRP, HCY increased with the ABI stage and the progress, the concentrations were negatively correlated with ABI value with a beta 2-microglobulin H-CRP HCY. Conclusion PAD with the severity of the condition, in the plasmaβ2-MG H-CRP HCY concentration increased gradually,the joint determination ofβ2-MG H-CRP HCY and ABI combined with a hierarchical diagnosis and prognosis of patients with PAD is helpful to make sound diagnosis.
出处
《医学研究与教育》
CAS
2015年第2期40-43,共4页
Medical Research and Education
