过敏性紫癜患儿血浆髓过氧化物酶、丙二醛、超氧化物歧化酶及总抗氧化能力水平变化被引量：31

Plasma myeloperoxidase, malondialdehyde, superoxide dismutase, and total anti-oxidant capability of Henoch-Schnlein purpura in children

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摘要目的：探讨过敏性紫癜（HSP）患儿血浆髓过氧化物酶（MPO）、丙二醛（MDA）、超氧化物歧化酶（SOD）及总抗氧化能力（T-AOC）水平的变化。方法收集2013年11月至2014年4月住院HSP患儿80例，其中关节型HSP 40例、腹型HSP 20例、紫癜性肾炎（HSPN）20例；同时选取健康体检儿童16例为对照组。采用化学比色法检测血浆MPO、T-AOC水平，采用硫代巴比妥酸比色法检测血浆MDA水平，采用羟胺法检测血浆SOD水平；并常规检测24 h尿蛋白定量及其他血液学指标。结果血浆MPO、MDA、SOD及T-AOC水平在对照组、关节型HSP组、腹型HSP组、HSPN组4组间差异有统计学意义（F=24.22～126.99，P均=0.000）。其中HSPN组的血浆MPO、MDA水平高于其他3组，而血浆SOD、T-AOC水平低于其他3组，差异有统计学意义（P均〈0.05）。腹型HSP组及关节型HSP组血浆MPO、MDA水平高于对照组， SOD、T-AOC水平低于对照组，差异也有统计学意义（P均〈0.05）。HSPN组患儿血浆MPO、MDA水平与其24 h尿蛋白排泄量呈显著正相关（r=0.695、0.559，P均〈0.01）。结论 HSP患儿存在氧化系统与抗氧化系统失衡。 ObjectiveTo investigate the changes in plasma myeloperoxidase （MPO）, malondialdehyde （MDA）, super-oxide dismutase （SOD） and total anti-oxidant capability （T-AOC） of Henoch-Schnlein purpura in children.MethodsA total of 80 HSP children hospitalized from November 2013 to April 2014 were selected including 40 cases of arthritis type, 20 cases of abdominal type and 20 cases of nephritis type （HSPN）. Meanwhile, 16 healthy check-up children were selected as controls. Plas-ma MPO, T-AOC levels were detected by chemical colorimetry and MDA levels were detected by thiobarbituric acid colorime-try. Plasma SOD levels were measured by hydroxylamine method. Furthermore, 24-hour urine protein and other hematological indices were routinely tested.ResultsThe plasma levels of MPO, MDA, SOD and T-AOC were signiifcantly different among control group, arthritis type group, abdominal type group and HSPN group （F=24.22-126.99, allP=0.000）. In comparison to oth-er three groups, the levels of MPO and MDA were signiifcantly increased and the levels of SOD and T-AOC were signiifcantly decreased in HSPN group （P〈0.05）. Compared with control group, the levels of MPO and MDA were signiifcantly higher and the levels of SOD and T-AOC were signiifcantly lower in arthritis and abdominal type groups （P〈0.05）. The levels of MPO and MDA in HSPN group were signiifcantly positively correlated with 24-hour urine protein （r=0.695, 0.559; bothP〈0.01）.Conclu-sionsThe imbalance between oxidation and antioxidant system exists in children with Henoch-Schnlein purpura.

作者李玉飞鹿玲

机构地区安徽医科大学第一附属医院儿科

出处《临床儿科杂志》 CAS CSCD 北大核心 2015年第4期357-360,共4页 Journal of Clinical Pediatrics

关键词过敏性紫癜髓过氧化物酶丙二醛超氧化物歧化酶总抗氧化能力 Henoch-Schonlein purpura myeloperoxidase malondialdehyde superoxide dismutase total anti-oxi-dant capability

分类号 R725.5 [医药卫生—儿科]

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