摘要
目的分析血浆髓过氧化物酶(MPO)和P选择素的联合检测对冠心病并高血压的临床意义。方法采用病例-对照研究方法,入选正常对照组(A组)56例,单纯冠心病患者(B组)64例,冠心病并高血压患者(C组)68例,应用酶联免疫吸附双抗体夹心法(ELISA)测定各组MPO和P选择素水平,并比较各组的MPO和P选择素水平,以及两者的相关关系。结果 C组MPO和P选择素水平均显著高于B组和A组,差异有统计学意义(P<0.01),B组MPO和P选择素水平亦高于A组,差异有统计学意义(P<0.05);C组MPO和P选择素水平呈正相关(r=0.62,P<0.05)。结论与正常对照组和单纯冠心病组相比,冠心病并高血压组患者MPO和P选择素的浓度显著升高,二者正相关性更强,二者联合检测可评估冠心病并高血压患者的病情,评价疗效和判断预后,为临床用药提供重要理论依据。
Objective To analyze the clinical meanings of joint measurements of myloperoxidase（MPO） and P-selectin of patients with coronary heart disease（CHD） and hypertensive disease（HD）.Methods By case-control research methods,total 56 persons in control group（group A）,64 patients with coronary heart disease（group B）,and 68 patients with coronary heart disease and hypertensive disease were chosen.The levels of plasma MPO and P-selectin were determined by enzyme-linked immunosorbent assay（ELISA）.The concentrations of plasma MPO,P-selectin and the correlativity were separately compared.Results The concentrations of plasma MPO,P-selectin were significantly higher in group C than group B and A（P0.01）.And the concentrations of plasma MPO,P-selectin were significantly higher in group B than group A（P0.05）.The levels of plasma MPO correlated positively with P-selectin in patients with coronary heart disease and hypertensive disease.Conclusion The concentrations of plasma MPO and P-selectin are significantly higher in the patients with coronary heart disease and hypertensive disease than those with coronary heart disease or control group.The joint measurements of the plasma MPO and P-selectin can be used to asses the condition,and evaluate curative effect and the prognosis in the patients with coronary heart disease and hypertensive disease,and to provide an important theoretical basis for clinical medication.
出处
《中国实用神经疾病杂志》
2012年第5期16-18,共3页
Chinese Journal of Practical Nervous Diseases
关键词
髓过氧化物酶
选择素
冠心病
高血压
Myloperoxidase
P-selectin
Coronary heart disease
Hypertensive disease
